Results 321 to 330 of about 210,920 (352)
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Tetrahedron, 1985
Abstract An intensive investigation of the marine animal AAmathia convoluta (Bryozoa phylum) for antineoplastic constituents has led to the isolation and structural determination of bryostatin 8 (2). A total of 100 kg of Amathia convoluta was required to obtain some 4.2 mg of bryostatin 8.
Dennis L. Doubek +6 more
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Abstract An intensive investigation of the marine animal AAmathia convoluta (Bryozoa phylum) for antineoplastic constituents has led to the isolation and structural determination of bryostatin 8 (2). A total of 100 kg of Amathia convoluta was required to obtain some 4.2 mg of bryostatin 8.
Dennis L. Doubek +6 more
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Thalidomide: An antineoplastic agent
Current Oncology Reports, 2002It has been more than three decades since the withdrawal of thalidomide from the marketplace. Thalidomide is attracting growing interest because of its reported immunomodulatory and anti-inflammatory properties. Current evidence indicates that thalidomide reduces the activity of the inflammatory cytokine tumor necrosis factor-alpha by accelerating the ...
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Butterfly wing antineoplastic agents
Experientia, 1972Eine Voruntersuchung der Insektengruppe Lepidoptera auf anti-tumor-aktive Stoffe fuhrte zu einer detaillierten chemischen Prufung der aus Asien stammenden SchmetterlingeCatopsilia crocale Cramer (Pieridae) undPieris rapae cruavora. Ein bedeutender Teil der Anti-Tumor-Aktivitat scheint ihren Ursprung in der chemischen Substanz Isoxanthopterin zu ...
Harry B. Wood +17 more
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Hypersensitivity to Antineoplastic Agents
Current Pharmaceutical Design, 2008The need to offer first line therapy for primary and recurrent cancers has spurred the clinical development of rapid desensitizations for chemotherapy and monoclonal antibodies. Rapid desensitizations allow patients to be treated with medications to which they have presented with hypersensitivity reactions (HSRs), including anaphylaxis.
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Antineoplastic Agents from Plants
Annual Review of Pharmacology and Toxicology, 1977Since at least 1500 Be plants and plant extracts have been recognized as having anticancer activities (1). Surveys by Hartwell (2, 3) listed at least 3000 species so used. However the rational, organized study of plants as sources of potential an tineoplastic agents probably commenced with the pioneering studies of Hartwell et al (4-8) during the ...
M. C. Wani, Monroe E. Wall
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Interaction of cyclosporin A with antineoplastic agents
Klinische Wochenschrift, 1985A synergistic effect of etoposide and cyclosporin A was observed in a patient with acute T-lymphocytic leukemia in relapse. The concomitant administration of etoposide and cyclosporin A resulted in eradication of hitherto refractory leukemic infiltration of bone marrow. Severe side effects in terms of mental confusion and progressive hyperbilirubinemia,
R. Osieka, O. Kloke
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Musculoskeletal Effects of Antineoplastic Agents
Journal of the American Academy of Orthopaedic Surgeons, 2019Cancer remains a common disease with approximately 40% of Americans diagnosed with cancer in their lifetime. Medical advances in the field of oncology have led to an increased life expectancy and a decreased mortality rate. Antineoplastic agents such as taxanes and targeted therapies are indicated in the treatment of many cancers, and their use can be ...
Izuchukwu K Ibe +3 more
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Antineoplastic Agents. 605. Isoquinstatins
Journal of Natural Products, 2017In order to further explore quinoline-type structural modification of the powerful anticancer drug dolastatin 10, an Indian Ocean sea hare constituent and parent molecule of the very successful antibody drug conjugate (ADC) Adcetris, our recent quinstatin study has been extended by replacing the quinoline ring with an isoquinoline.
George R. Pettit +2 more
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Vascular Toxicity of Antineoplastic Agents
Seminars in Oncology, 2006Among the various deleterious effects of cancer chemotherapy, vascular toxicity is the least well recognized. This lack of recognition may be because the vasculotoxic phenomena are not unique to antineoplastic agents, can occur in patients without exposure to these agents, and the fact cancer itself may produce a hypercoagulable state.
Syed Haider +2 more
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Pharmacology of antineoplastic agents in pregnancy
Critical Reviews in Oncology/Hematology, 1994The use of antineoplastic agents in pregnant women poses obvious risks to both the patient and the developing fetus, particularly during organogenesis. While the use of antineoplastics during pregnancy is often unavoidable, the physician may limit the risks by having a clear knowledge of the pharmacology and teratogenic potential of individual agents ...
Valerie J. Wiebe, Pirkko Sipilä
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