Adherence to prescribing restrictions for HER2-positive metastatic breast cancer in Australia: A national population-based observational study (2001-2016) [PDF]
, 2018 Background: Targeted cancer therapy is often complex, involving multiple agents and chemotherapeutic partners. In Australia, prescribing restrictions are put in place to reflect existing evidence of cost-effectiveness of these medicines.
Daniels, Benjamin +6 more
core +2 more sources
Improving the Brain Delivery of Chemotherapeutic Drugs in Childhood Brain Tumors [PDF]
, 2019 The central nervous system (CNS) may be considered as a sanctuary site, protected from systemic chemotherapy by the meninges, the cerebrospinal fluid (CSF) and the blood-brain barrier (BBB).
Attin\ue0, Giorgio +5 more
core +1 more source
Antibacterial activities of antineoplastic agents [PDF]
Antimicrobial Agents and Chemotherapy, 1985 Fourteen antineoplastic agents were examined for in vitro antibacterial activity against 101 aerobic and anaerobic bacterial isolates representing indigenous human microflora and selected opportunistic pathogens. Only 5-fluorouracil, mitomycin, and etoposide demonstrated inhibitory effects at achievable plasma concentrations, while the remaining drugs ...
James H. Jorgensen +2 more
openaire +3 more sources
Paravasation with cyclophosphamide - Case report of tissue necrosis in a patient with primary breast cancer [PDF]
, 2007 Background: Paravasation is a rare but severe complication of treatment with cytotoxic agents. Some anticancer drugs are considered to be of high toxicity (vesicant), some are merely irritant, and some are regarded as nearly non-toxic to healthy tissue ...
Adami NP +7 more
core +1 more source
Evaluation of cytotoxic activity of live toxoplasma gondii tachyzoites and toxoplasma antigen on MCF-7 human breast cancer cell line [PDF]
, 2022 The aim of this study was to investigate the cytotoxic potency of live Toxoplasma gondii tachyzoites as well as Toxoplasma antigen on MCF-7 human breast cancer cell line.
Eissa, Maha M. +4 more
core +3 more sources
Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents
Chemical Biology and Drug Design, 2018 Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been implicated with human life since ancient time, far earlier than their isolation and identification in modern era. The long use history of naphthoquinones has witnessed
Han‐Yue Qiu +5 more
semanticscholar +1 more source
Fatherhood and sperm DNA damage in testicular cancer patients [PDF]
, 2018 Testicular cancer (TC) is one of the most treatable of all malignancies and the management of the quality of life of these patients is increasingly important, especially with regard to their sexuality and fertility.
Lenzi, Andrea +3 more
core +1 more source
Brazilian Journal of Oncology, 2021 Introduction: Standard treatment for pediatric patients with localized osteosarcoma includes high-dose methotrexate (HDMTX), and cure rates greater than 60% are observed.
Marilia Polo Minguete-e-Silva +11 more
doaj +1 more source
Genetic and Modifiable Risk Factors Contributing to Cisplatin-Induced Toxicities [PDF]
, 2019 Effective administration of traditional cytotoxic chemotherapy is often limited by off-target toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent that has potent antineoplastic activity due to its affinity for DNA and other ...
Dinh, Paul C. Jr. +4 more
core +1 more source
Potential drug interactions between oral antineoplastic agents and opioid analgesics [PDF]
, 2022 Oral antineoplastic drugs use has been gaining more importance due to its multiple benefits and the introduction of new molecules with new mechanisms of action.
Antunes, Cláudia +2 more
core +1 more source