Results 41 to 50 of about 175,055 (304)

Anti-mutagenic and Pro-apoptotic Effects of Apigenin on Human Chronic Lymphocytic Leukemia Cells [PDF]

Acta Medica Iranica, 2010
Diet can play a vital role in cancer prevention. Nowadays the scientists are looking for food materials which can potentially prevent the cancer occurrence.
Mehrdad Hashemi, Mehdi Nouri Long, Maliheh Entezari, Shohreh Nafisi, Hossein Nowroozii   +4 more
doaj   +1 more source

Bioequivalence study between two formulations of 10mg lenalidomide capsules in healthy male subjects under fasting conditions

Brazilian Journal of Oncology, 2023
OBJECTIVE: To evaluate pharmaceutical bioequivalence between two formulations of 10mg lenalidomide capsules in healthy male subjects under fasting conditions.
Carlos Sverdloff, Vinicius Marcondes Rezende, Ligia de Cassia Val, Nelly Cristina Castro, Maria Elena Cedano Limón, Mohammad H. Badii, Sreekanth Kakarla, Murali Pendela, Lygia Bonnato   +8 more
doaj   +1 more source

Unusual DNA binding modes for metal anticancer complexes [PDF]

, 2009
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
core   +1 more source

Medical treatment of early stage and rare histological variants of epithelial ovarian cancer [PDF]

, 2015
Epithelial ovarian cancer is often considered a single pathological entity, but increasing evidence suggests that it is rather a group of different neoplasms, each with unique pathological characteristics, molecular features, and clinical behaviours ...
Biglia, Nicoletta, CODACCI PISANELLI, Giovanni, Colombo, Nicoletta, Cont, Nicoletta Tomasi, D'Alonzo, Marta, Ferrero, Annamaria, Peccatori, Fedro Alessandro   +6 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Peritoneal regression grading score (PRGS): first evidence for independent predictive and prognostic significance

Pleura and Peritoneum, 2023
The peritoneal regression grading score (PRGS) is a four-tied pathologic score measuring tumor regression in biopsies from patients with peritoneal metastasis (PM) receiving chemotherapy.
Baake Janina, Nadiradze Giorgi, Archid Rami, Königsrainer Alfred, Bösmüller Hans, Reymond Marc, Solass Wiebke   +6 more
doaj   +1 more source

Future of 5-fluorouracil in cancer therapeutics, current pharmacokinetics issues and a way forward [PDF]

, 2019
Background: In addition to exhibiting antitumor potential, antitumor drugs exhibit toxicity due to a poor pharmacokinetic profile. An enormous amount of research has been carried out and is still ongoing to obtain more targeted, potent, and safe drugs to
Abd-Rabou, Anitha, Arias, Atrián-Blasco, Berners-Price, Bertrand, Carrillo, Chandran, Chibaudel, Clingan, DiGiulio, Esin, Gao, Gasser, Hoste, Li, Liu, Liu, Luo, Miura, Mohana, Moloney, Nadzri, Nisa, Nivethaa, Nunes, Rambabu, Rengaraj, Saǧir, Shaima, Shen, Subudhi, Sun, Tummala, Wang, Yu, Zhang, Zhang, Zhu, Álvarez   +39 more
core   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Evaluation of Electrocardiographic Repolarization Parameters in Patients who Received Ribociclib and Palbociclib Therapy

Indian Journal of Medical Specialities, 2023
Introduction: Ribociclib and palbociclib are the inhibitors of cyclin-dependent kinase (CDK) 4/6 activity which have been used in the treatment of metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2-negative breast cancer.
Gülçin Sahingöz Erdal, Dilay Karabulut, Cennet Yildiz, Nilgun Isiksacan, Ersan Oflar, Fatma Nihan Turhan Çaglar, Osman Pirhan, Hasan Ali Sinoplu, Fahrettin Katkat, Deniz Tural   +9 more
doaj   +1 more source

Genetic and Modifiable Risk Factors Contributing to Cisplatin-Induced Toxicities [PDF]

, 2019
Effective administration of traditional cytotoxic chemotherapy is often limited by off-target toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent that has potent antineoplastic activity due to its affinity for DNA and other ...
Dinh, Paul C. Jr., Dolan, M., El Charif, Omar, Travis, Lois B., Trendowski, Matthew R.   +4 more
core   +1 more source