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A Genetic Risk Variant Associated With the Risk of Primary Biliary Cholangitis Is Inherited From Neanderthals
Liver International, Volume 46, Issue 10, October 2026.ABSTRACT Background
Primary Biliary Cholangitis (PBC) is an autoimmune cholangiopathy with polygenic architecture and unknown aetiology. Evidence links Neanderthal‐derived genetic variants to autoimmune conditions; however, their contribution to PBC susceptibility remains unexplored.Alessio Gerussi, Chiara Caime, Harold Wang, Heather J. Cordell, George F. Mells, Richard N. Sandford, David E. Jones, Gideon Hirschfield, Katherine A. Siminovitch, M. Eric Gershwin, Brian D. Juran, Elizabeth J. Atkinson, Angela Cheung, Mariza de Andrade, Aris Baras, Konstantinos N. Lazaridis, Rosanna Asselta, Pietro Invernizzi, Manuela Sironi, Sriram Sankararaman, Canadian‐US PBC Consortium, UK‐PBC Consortium, James J. Fryett, Rebecca Darlay, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Richard Sturgess, Christopher Healey, Andrew Yeoman, Anton Vj Gunasekera, Paul Kooner, Kapil Kapur, V. Sathyanarayana, Yiannis Kallis, Javaid Subhani, Rory Harvey, Roger McCorry, Paul Rooney, David Ramanaden, Richard Evans, Thiriloganathan Mathialahan, Jaber Gasem, Christopher Shorrock, Mahesh Bhalme, Paul Southern, Jeremy A. Tibble, David A. Gorard, Susan Jones, Brijesh Srivastava, Matthew R. Foxton, Carole E. Collins, David Elphick, Mazn Karmo, Francisco Porras‐Perez, Michael Mendall, Tom Yapp, Minesh Patel, Roland Ede, Joanne Sayer, James Jupp, Neil Fisher, Martyn J. Carter, Konrad Koss, Jayshri Shah, Andrzej Piotrowicz, Glyn Scott, Charles Grimley, Ian R. Gooding, Simon Williams, Judith Tidbury, Guan Lim, Kuldeep Cheent, Sass Levi, Dina Mansour, Matilda Beckley, Coral Hollywood, Terry Wong, Richard Marley, John Ramage, Harriet M. Gordon, Jo Ridpath, Theodore Ngatchu, Vijay Paul Bob Grover, Ray G. Shidrawi, George Abouda, L. Corless, Mark Narain, Ian Rees, Ashley Brown, Simon Taylor‐Robinson, Joy Wilkins, Leonie Grellier, Paul Banim, Debasish Das, Michael A. Heneghan, Howard Curtis, Helen C. Matthews, Faiyaz Mohammed, Mark Aldersley, Raj Srirajaskanthan, Giles Walker, Alistair McNair, Amar Sharif, Sambit Sen, George Bird, Martin I. Prince, Geeta Prasad, Paul Kitchen, Adrian Barnardo, Chirag Oza, Nurani N. Sivaramakrishnan, Prakash Gupta, Amir Shah, Chris Dj Evans, Subrata Saha, Katharine Pollock, Peter Bramley, Ashis Mukhopadhya, Stephen T. Barclay, Natasha McDonald, Andrew J. Bathgate, Kelvin Palmer, John F. Dillon, Simon M. Rushbrook, Robert Przemioslo, Chris McDonald, Andrew Millar, Cheh Tai, Stephen Mitchell, Jane Metcalf, Syed Shaukat, Mary Ninkovic, Udi Shmueli, Andrew Davis, Asifabbas Naqvi, Tom Jw Lee, Stephen Ryder, Jane Collier, Howard Klass, Matthew E. Cramp, Nichols Sharer, Richard Aspinall, Deb Ghosh, Andrew C. Douds, Jonathan Booth, Earl Williams, Hyder Hussaini, John Christie, Steven Mann, Douglas Thorburn, Aileen Marshall, Imran Patanwala, Aftab Ala, Julia Maltby, Ray Matthew, Chris Corbett, Sam Vyas, Saket Singhal, Dermot Gleeson, Sharat Misra, Jeff Butterworth, Keith George, Tim Harding, Andrew Douglass, Harriet Mitchison, Simon Panter, Jeremy Shearman, Gary Bray, Michael Roberts, Graham Butcher, Daniel Forton, Zahid Mahmood, Matthew Cowan, Debashis Das, Chin Lye Ch'ng, Mesbah Rahman, Gregory C. A. Whatley, Emma Wesley, Aditya Mandal, Sanjiv Jain, Stephen P. Pereira, Mark Wright, Palak Trivedi, Fiona H. Gordon, Esther Unitt, Altaf Palejwala, Andrew Austin, Vishwaraj Vemala, Allister Grant, Andrew D. Higham, Alison Brind, Ray Mathew, Mark Cox, Subramaniam Ramakrishnan, Alistair King, Simon Whalley, Jocelyn Fraser, S. J. Thomson, Andrew Bell, Voi Shim Wong, Richard Kia, Ian Gee, Richard Keld, Rupert Ransford, James Gotto, Charles Millson, Italian PBC Genetics Study Group, Andrea Affronti, Maurizia Brunetto, Barbara Coco, Giancarlo Spinzi, Gianfranco Elia, Carlo Ferrari, Ana Lleo, Luigi Muratori, Paolo Muratori, Piero Portincasa, Agostino Colli, Savino Bruno, Guido Colloredo, Francesco Azzaroli, Pietro Andreone, MariaConsiglia Bragazzi, Domenico Alvaro, Vincenzo Cardinale, Nora Cazzagon, Annarosa Floreani, Cristina Rigamonti, Floriano Rosina, Marco Carbone, Laura Cristoferi, Marco Festa, Eugenia Nofit, Miki Scaravaglio, Daphne D'Amato, Federica Malinverno, Pietro Lampertico, Francesca Donato, Stefano Fagiuoli, Piero L. Almasio, Edoardo Giannini, Carmela Cursaro, Massimo Colombo, Luca Valenti, Luca Miele, Angelo Andriulli, Grazia A. Niro, Ignazio Grattagliano, Lorenzo Morini, Giovanni Casella, Maria Vinci, Pier Maria Battezzati, Andrea Crosignani, Massimo Zuin, Alberto Mattalia, Vincenza Calvaruso, Silvia Colombo, Antonio Benedetti, Marco Marzioni, Andrea Galli, Fabio Marra, Mirko Tarocchi, Antonio Picciotto, Filomena Morisco, Luca Fabris, Lory Saveria Crocè, Claudio Tiribelli, Pierluigi Toniutto, Mario Strazzabosco +269 morewiley +1 more sourceGenetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease. [PDF]
Lupus Sci MedKhan A, Karakoc G, Liu G, Zanussi J, Olsen NJ, Shi M, Cox NJ, Mosley J, Stein CM, Kiryluk K, Wei WQ, Mentch F, Hebbring S, Linneman J, Kawai V. +14 moreeuropepmc +1 more sourceAssociation of antinuclear antibody positivity with liver disease severity in pediatric metabolic dysfunction-associated steatotic liver disease. [PDF]
Front PediatrKim HJ, Kim JY, Lee YM, Hong YH, Kang B, Choe BH, Yi DY, Lee EH, Kim SC, Choi YJ, Jang HJ, Choi SY. +11 moreeuropepmc +1 more source
