Results 41 to 50 of about 538,466 (312)

Antioxidant enzymes, presbycusis, and ethnic variability [PDF]

Otolaryngology–Head and Neck Surgery, 2010
OBJECTIVEA proposed mechanism for presbycusis is a significant increase in oxidative stress in the cochlea. The enzymes glutathione S‐transferase (GST) and N‐acetyltransferase (NAT) are two classes of antioxidant enzymes active in the cochlea. In this work, we sought to investigate the association of different polymorphisms of GSTM1, GSTT1, and NAT2 ...
Anthony, Bared, Xiaomei, Ouyang, Simon, Angeli, Li Lin, Du, Kimberly, Hoang, Denise, Yan, Xue Zhong, Liu   +6 more
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Antioxidant, antimicrobial, enzyme inhibitory and cytotoxic effect of Taverniera couneifolia plant mediated Silver nanoparticles

Liaquat Medical Research Journal
This study was conducted to evaluate antioxidant, anticancer, enzyme inhibitory and antimicrobial potential of methanolic extract and AgNPs of T. couneifolia.
Rahmat Khan, Muhammad Nisar Ul Haq, Ghulam Mujtaba Shah, Wahid Ullah, Khursheed Ur Rahman, Zamarud Shah, Ammara Khan, Feroz Khan, Matiullah, Ihsan Ullah, Hajra Afeera Hamid, Hajra Afeera Hamid   +11 more
doaj   +1 more source

Antioxidant and antihypertensive activities of rice bran peptides [PDF]

, 2011
Protein isolates and peptide fractions from food sources (cereal grains), have been shown to exert bioactive properties including antiobesity, anticancer, antiangiogenic, etc.
Hettiarachchy, Navam S., Hull, Janika, Kannan, Arvind   +2 more
core   +2 more sources

Cu,Zn superoxide dismutase genes in Tribolium castaneum: evolution, molecular characterisation and gene expression during immune priming. [PDF]

, 2017
The production of reactive oxygen species (ROS) is a normal consequence of the aerobic cell metabolism. Despite their high and potentially detrimental reactivity with various biomolecules, the endogenous production of ROS is a vital part of physiological,
Bakiu, Rigers, Corr\ue0, Francesca, Ferro, Diana, Kevin, Ferro, Kurtz, Joachim, Santovito, Gianfranco   +5 more
core   +2 more sources

Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes

World Journal of Gastroenterology, 2016
Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide. The metabolism of ethanol generates reactive oxygen species, which play a significant role in the deterioration of alcoholic liver disease (ALD). Antioxidant phytochemicals, such as polyphenols, regulate the expression of ALD-associated proteins and peptides ...
Kyu-Ho, Han, Naoto, Hashimoto, Michihiro, Fukushima   +2 more
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Does Oxidative Stress Promote The Effect of The Paraoxonase Enzyme Family (PON) On Cancer? A Review Study to Clarify This Relationship by PONs

Sakarya Tıp Dergisi, 2022
Cancer development and progression are associated with oxidative stress. Oxidative stress can favor high concentrations of reactive oxygen species (ROS), and free radicals are associated with antioxidant metabolism.
Muhammet Örnek, Tugba Kevser Uysal, Özen Özensoy Güler   +2 more
doaj   +1 more source

Efecto del estrés producido por la mezcla de sales en la concentración de aldehído malónico, proteínas y enzimas antioxidantes de Leymus chinensis de tres colores foliares diferentes [PDF]

, 2017
The mixed salt stress is common in nature. Salt stressalways affects plant growth. Different plant species have different adaptive capacity to salty soil. Leymus chinensis is an herbaceous plant with different leaf colors.
Busso, Carlos Alberto, Han, X. G., Wang, Z. W., Yang, Y. F., Yang, Y. G., Zhang, Z., Zhou, C.   +6 more
core