Results 31 to 40 of about 28,997 (288)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara +5 more
wiley +1 more source
Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases
Tropical Medicine and Infectious DiseaseParasitic diseases represent a severe global burden, with current treatments often limited by toxicity, drug resistance, and suboptimal efficacy in chronic infections.
Jaime A. Isern +3 more
doaj +1 more source
Iron Oxide Nanoparticles: Green Synthesis and Their Antimicrobial Activity
Nanomaterials, 2023 The rise of antimicrobial resistance caused by inappropriate use of these agents in various settings has become a global health threat. Nanotechnology offers the potential for the synthesis of nanoparticles (NPs) with antimicrobial activity, such as iron
Johana Zúñiga-Miranda +7 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Graduating medical students consistently report being unprepared for the complexity of prescribing in clinical practice. Current clinical prescribing teaching and authentic assessment are limited due to patient safety concerns. We aimed to examine the educational utility of supervised preprescribing as a learning process and potential authentic ...
Kellie A. Charles +7 more
wiley +1 more source
Review on the Applications of Selected Metal-Based Complexes on Infectious Diseases
MoleculesFatalities caused by infectious diseases (i.e., diseases caused by parasite, bacteria, and viruses) have become reinstated as a major public health threat globally. Factors such as antimicrobial resistance and viral complications are the key contributors
Nondumiso P. Dube +5 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims The aim of this study was to describe prescription use of acetaminophen, a widely used analgesic and antipyretic generally considered safe during pregnancy, among pregnant women from 2000 to 2023 in Denmark with special attention towards variations following the change in over‐the‐counter (OTC) availability in 2013.
Erika B. Gram +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon +12 more
wiley +1 more source
Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential [PDF]
, 2021 Nayara Sousa da Silva +10 more
openalex +1 more source
Biotechnology Progress, EarlyView.Fusion of a 27‐amino‐acid peptide tag derived from a glycolytic enzyme enabled artificial assembly formation of the two violacein biosynthetic enzymes, VioE and VioC. This assembly resulted in enhanced biosynthesis of deoxyviolacein. Abstract In microbial production, regulating endogenous and exogenous synthetic pathways is essential.
Rioko Ito +4 more
wiley +1 more source