Results 1 to 10 of about 23,125 (311)

Repurposing Potential of the Antiparasitic Agent Ivermectin for the Treatment and/or Prophylaxis of COVID-19 [PDF]

Pharmaceuticals, 2022
Due to the rapid, vast, and emerging global spread of the Coronavirus Disease 2019 (COVID-19) pandemic, many drugs were quickly repurposed in a desperate attempt to unveil a miracle drug. Ivermectin (IVM), an antiparasitic macrocyclic lactone, was tested
Hoda Awad, Basmala Hassan, Sara Dweek, Yasmeen Aboelata, Mutasem Rawas-Qalaji, Iman Saad Ahmed   +5 more
doaj   +4 more sources

Arylmethylamino steroids as antiparasitic agents [PDF]

Nature Communications, 2017
AbstractIn search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (IC50 1–5 nM) as well as against gametocytes. In
Krieg, Reimar, Jortzik, Esther, Goetz, Alice-Anne, Blandin, Stéphanie, Wittlin, Sergio, Elhabiri, Mourad, Rahbari, Mahsa, Nuryyeva, Selbi, Voigt, Kerstin, Dahse, Hans-Martin, Brakhage, Axel, Beckmann, Svenja, Quack, Thomas, Grevelding, Christoph G., Pinkerton, Anthony B., Schönecker, Bruno, Burrows, Jeremy, Davioud-Charvet, Elisabeth, Rahlfs, Stefan, Becker, Katja, Justus Liebig University Giessen   +20 more
core   +12 more sources

Antiparasitic Agent Atovaquone [PDF]

Antimicrobial Agents and Chemotherapy, 2002
Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. There
Aaron L, Baggish, David R, Hill
  +6 more sources

S-Methyl-(2-Methoxycarbonylamino-Benzimidazole-5) Thiosulfonate as a Potential Antiparasitic Agent—Its Action on the Development of Ascaris suum Eggs In Vitro [PDF]

Pharmaceuticals, 2020
Ascaris suum is a soil-transmitted parasite causing ascariasis in pigs, largely limiting livestock production globally. Searching for new drugs affecting all stages of nematode development is necessary and widely postulated.
Małgorzata Dmitryjuk, Magdalena Szczotko, Katarzyna Kubiak, Radosław Trojanowicz, Zhanna Parashchyn, Halyna Khomitska, Vira Lubenets   +6 more
doaj   +2 more sources

Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone [PDF]

Marine Drugs, 2020
The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
Concetta Imperatore, Roberto Gimmelli, Marco Persico, Marcello Casertano, Alessandra Guidi, Fulvio Saccoccia, Giovina Ruberti, Paolo Luciano, Anna Aiello, Silvia Parapini, Sibel Avunduk, Nicoletta Basilico, Caterina Fattorusso, Marialuisa Menna   +13 more
doaj   +3 more sources

Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease. [PDF]

Antimicrob Agents Chemother, 2018
Nixon GL, McEntee L, Johnson A, Farrington N, Whalley S, Livermore J, Natal C, Washbourn G, Bibby J, Berry N, Lestner J, Truong M, Owen A, Lalloo D, Charles I, Hope W.   +15 more
europepmc   +3 more sources

Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer. [PDF]

Oncotarget, 2017
Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.   +16 more
europepmc   +3 more sources

Phosphonium lipocations as antiparasitic agents [PDF]

Bioorganic & Medicinal Chemistry Letters, 2012
Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P.
Timothy E, Long, Xiao, Lu, Melina, Galizzi, Roberto, Docampo, Jiri, Gut, Philip J, Rosenthal   +5 more
openaire   +4 more sources

A Review of FDA-Approved Antiparasitic Drugs in USA for Sheep and Goats: Their Synthesis and Pharmaceutical Use [PDF]

Trends in Pharmaceutical Sciences, 2023
This review describes the Food and Drug Administration (FDA)-approved antiparasitic drugs for sheep and goats in the USA updated to 2021. The emerging drug resistance is posing a significant burden for the treatment of parasitic infections in these small
Davide Benedetto Tiz, Črtomir Podlipnik
doaj   +1 more source

Staphylococcus aureus’s golden-yellow pigment staphyloxanthin: production enhancement, analytical characterization, and biological attributes [PDF]

Microbial Cell Factories
Staphyloxanthin (STX), an apocarotenoid golden yellow pigment produced by Staphylococcus aureus isolates, is endowed with potent antioxidant capacity. It plays a crucial role in combating reactive oxygen species (ROS), exhibiting considerable application
Ahmed M. Nosair, Amal M. Abo-Kamar, Lamiaa A. Al-Madboly, Mahmoud H. Farghali, Ahmed A. Abdelaziz   +4 more
doaj   +2 more sources