Results 21 to 30 of about 23,125 (311)

Polyaromatic Bis(indolyl)methane Derivatives with Antiproliferative and Antiparasitic Activity

Molecules, 2023
Bis(indolyl)methanes (BIMs) are a class of compounds that have been recognized as an important core in the design of drugs with important pharmacological properties, such as promising anticancer and antiparasitic activities.
Raquel C. R. Gonçalves, Pablo Peñalver, Susana P. G. Costa, Juan C. Morales, Maria Manuela M. Raposo   +4 more
doaj   +1 more source

Drug Repurposing of the Alcohol Abuse Medication Disulfiram as an Anti-Parasitic Agent

Frontiers in Cellular and Infection Microbiology, 2021
Parasitic infections contribute significantly to worldwide morbidity and mortality. Antibiotic treatment is essential for managing patients infected with these parasites since control is otherwise challenging and there are no vaccines available for ...
Debbie-Ann Shirley, Ishrya Sharma, Cirle A. Warren, Shannon Moonah   +3 more
doaj   +1 more source

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]

, 2020
A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia, Cabral, Lília, Cojean, Sandrine, Cristiano, Maria De Lurdes, Loiseau, Philippe M., Pomel, Sébastien   +5 more
core   +1 more source

Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency

Molecules, 2021
A tailored series of coumarin-based ferrocenyl 1,3-oxazine hybrid compounds was synthesized and investigated for potential antiparasitic activity, drawing inspiration from the established biological efficacy of the constituent chemical motifs.
Mziyanda Mbaba, Laura M. K. Dingle, Ayanda I. Zulu, Dustin Laming, Tarryn Swart, Jo-Anne de la Mare, Heinrich C. Hoppe, Adrienne L. Edkins, Setshaba D. Khanye   +8 more
doaj   +1 more source

Annona muricata Leaf as an Anti-Cryptosporidial Agent: An In Silico Molecular Docking Analysis and In Vivo Studies

Pharmaceuticals, 2023
Cryptosporidiosis is a serious parasitic diarrheal disease linked to the occurrence of colorectal cancer in immunocompromised patients. The FDA-approved drug nitazoxanide (NTZ) achieved a temporary effect, and relapses occur.
Eman S. El-Wakil, Hagar F. Abdelmaksoud, Majed H. Wakid, Muslimah N. Alsulami, Olfat Hammam, Haleema H. Albohiri, Marwa M. I. Ghallab   +6 more
doaj   +1 more source

A brief overview of current drug repurposing approaches for COVID-19 management [PDF]

, 2020
This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares, Thomaz, Douglas Vieira   +1 more
core   +2 more sources

Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. [PDF]

, 2006
Immunophilin is the collective name given to the cyclophilin and FK506-binding protein (FKBP) families. As the name suggests, these include the major binding proteins of certain immunosuppressive drugs: cyclophilins for the cyclic peptide cyclosporin A ...
Adams, Aliberti, Alphey, Angus Bell, Antony P. Page, Argaet, Banerjee, Banumathy, Belfiore, Bell, Bell, Bell, Berriman, Blumenthal, Blumenthal, Borel, Bozdech, Braun, Bua, Carlton, Chakraborty, Chakraborty, Chappell, Chappell, Cianciotto, Cohen, Colgan, Dao-Thi, Denkers, Dobson, Dolinski, Dornan, Dornan, Dutta, Fischer, Florens, Galat, Galat, Gavigan, Gavigan, Gilleard, Golding, Hacker, Hall, High, Hirtzlin, Hong, Hope, Kamath, Kay, Ke, Khattab, Kiang, Klinkert, Klinkert, Knobloch, Kumar, Kumar, Kumar, Le Roch, Lightowlers, Lorberg, Ma, Ma, Ma, Matsuda, McLauchlan, Mikol, Monaghan, Monaghan, Moro, Osman, Ostoa-Saloma, Oz, Page, Page, Page, Page, Page, Page, Page, Paul Monaghan, Pelle, Pereira, Peterson, Picken, Pratt, Rascher, Reddy, Riggs, Rossi, Shirane, Silverman, Taylor, Tuo, Valle, Wang, Weiwad, Williams, Yarovinsky, Yu, Zorio   +101 more
core   +1 more source

Overview of Genus Prosopis Toxicity Reports and its Beneficial Biomedical Properties [PDF]

, 2016
Secondary plant metabolites are regarded as promising sources of plant-protecting substances and they are one of the most important lines of plant defense against pests. The range of cellular targets for these substances is very wide and covers metabolic
Gamarra Luques, Carlos Diego, Hapon, María Belén, Persia, Andres, Rinaldini, Estefanía   +3 more
core   +1 more source

Effects of the repeated distribution of sainfoin hay on the resistance and the resilience of goats naturally infected with gastrointestinal nematodes [PDF]

, 2005
Due to the high prevalence of anthelmintic resistance in goats, the need to explore novel approaches to control nematodes and to reduce the exclusive reliance on chemotherapy is strongly demanded in this host species.
F., De La Farge, F., Prevot, H., Hoste, Ph., Dorchies, V., Paolini   +4 more
core   +1 more source

Identification of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin [PDF]

Journal of Biological Chemistry, 1996
Doris Cully, Philip S. Paress, Ken K. Liu, James M. Schaeffer, Joseph P. Arena   +4 more
openalex   +3 more sources