Results 41 to 50 of about 28,997 (288)
Chemistry &Biodiversity, EarlyView.ABSTRACT Porcelia macrocarpa is a Brazilian plant species belonging to the Annonaceae family. To date, more than 190 compounds have been identified and/or isolated from this species, with terpenoids comprising the majority (62%). Alkaloids represent the second most abundant class (11%), followed by steroids (4%), acetogenins (4%), fatty acids (4 ...
Fernanda Thevenard +4 more
wiley +1 more source
The Phylum Bryozoa: From Biology to Biomedical Potential
Marine Drugs, 2020 Less than one percent of marine natural products characterized since 1963 have been obtained from the phylum Bryozoa which, therefore, still represents a huge reservoir for the discovery of bioactive metabolites with its ~6000 described species.
Maria Letizia Ciavatta +7 more
doaj +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy +4 more
wiley +1 more source
Phenolic Profile and Bioactive Prospects of Wild Annona Species From Angola
Chemistry &Biodiversity, EarlyView.ABSTRACT Annona species (Annonaceae family) are valued for their nutritional and medicinal importance, especially in traditional medicine. This study investigated the phenolic profiles of the Angolan Annona muricata, Annona squamosa, and Annona senegalensis leaves, stem barks, and seeds hydroethanolic, infusion, and decoction extracts, also evaluating ...
Josefa Rangel +9 more
wiley +1 more source
PharmaceuticalsBackground/Objectives: Leishmaniasis, a neglected disease caused by Leishmania spp. including L. amazonensis, urgently requires new treatments. Polyalthic acid (PA), a natural diterpene from Copaifera spp., has previously demonstrated significant ...
Ana Carolina Bolela Bovo Candido +7 more
doaj +1 more source
Mānuka Oil—A Review of Antimicrobial and Other Medicinal Properties
Pharmaceuticals, 2020 Mānuka oil is an essential oil derived from Leptospermum scoparium, a plant that has been used by the indigenous populations of New Zealand and Australia for centuries.
Cynthia Mathew +6 more
doaj +1 more source
ChemMedChem, EarlyView.Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco +11 more
wiley +1 more source
Pharmaceuticals, 2020 The synthesis, characterization, and in vitro antiparasitic and anticancer activity evaluation of new conjugates containing two and three dinuclear trithiolato-bridged ruthenium(II)-arene units are presented.
Valentin Studer +13 more
doaj +1 more source
Antiparasitic Drugs in Children
Clinical Pharmacokinetics, 1989 Many of the children living in tropical areas of the world are infected by a variety of human parasites. As a group, the antiparasitic drugs can claim to be the least studied of all compounds in current clinical use. There is little information on the disposition of these drugs in children, and most treatment recommendations are either empirical or by ...
openaire +2 more sources
ChemMedChem, EarlyView.Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri +14 more
wiley +1 more source