Results 171 to 180 of about 3,292,255 (346)

Switching Metazoan Fatty Acid Synthase Between Reducing and Nonreducing Elongation Mode via Programming of the Ketoreductase Domain

ChemBioChem, Volume 27, Issue 2, January 2026.
Striving to shed light on programming of iterative polyketide synthases (PKSs), we introduced a helix motif found in iterative PKS ketoreductase domains into an evolutionary related fatty acid synthase. With this, we were able to impose programming, switching between a reducing and nonreducing elongation mode.
Damian L. Ludig, André Herber, Martin Grininger   +2 more
wiley   +1 more source

Antiparasitic Agents

, 2017
F. Matthew Kuhlmann, James M. Fleckenstein   +1 more
openaire   +2 more sources

Unprecedented Nitrite‐Dependent Aromatic Amination to Synthesize 2,4‐Diamino‐3‐Hydroxybenzoic Acid

ChemBioChem, Volume 27, Issue 2, January 2026.
By comparing the biosynthetic gene clusters for natural products with 2,4‐diamino‐3‐hydroxybenzoic acid (2,4,3‐DAHBA) moiety and heterologous expression in Streptomyces albus, we identified nine genes required for the biosynthesis of 2,4,3‐DAHBA, including nitrite biosynthesis genes.
Ko Kuwabara, Yohei Katsuyama, Yasuo Ohnishi   +2 more
wiley   +1 more source

Genetic and structural study of DNA-directed RNA polymerase II of Trypanosoma brucei, towards the designing of novel antiparasitic agents

, 2017
Louis Papageorgiou, Vasileios Megalooikonomou, Dimitriοs Vlachakis   +2 more
openalex   +1 more source

Hydatid Cyst in a Post‐Tuberculosis Patient: A Persistent Pulmonary Puzzle – A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Pulmonary tuberculosis and hydatid cyst are two distinct pathologies with vastly different etiologies and management approaches, yet they share common risk factors and pulmonary involvement. This rare and unique case of a hydatid cyst occurring in a post‐tuberculosis patient adds to the limited literature and highlights the diagnostic and ...
Abdul Rehman Shahid, Amina Asad, Janmejay Kumar Singh, Malik Muhammad Kabir, Kainat Husain, Khalil El Abdi, Fazeela Bibi, Muhammad Hassan, Bilal Aslam, Said Hamid Sadat   +9 more
wiley   +1 more source

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 1, January 2026.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão   +11 more
wiley   +1 more source

Beautyberry (Callicarpa arborea) as an Antiparasitic Agent Against Raillietina echinobothrida, an Intestinal Tapeworm [PDF]

, 2020
Pawi Bawitlung Lalthanpuii, Kholhring Lalchhandama   +1 more
openalex   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs [PDF]

, 2017
Objectives The protozoan parasite Giardia lamblia causes the intestinal disease giardiasis, which may lead to acute and chronic diarrhoea in humans and various animal species.
Müller, Joachim, Müller, Norbert, Nillius, Dorothea   +2 more
core  

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source