Results 111 to 120 of about 3,678,963 (228)

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

What We Can Do in Infectious Keratitis, Except for Conventional Antimicrobial‐Based Therapies: Major Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Infectious keratitis (IK) is classified as a critical ophthalmic emergency, with the potential to result in vision‐impairing complications. The treatment approach involves the use of pharmacological antimicrobial agents in combination with surgical interventions.
Kasra Cheraqpour
wiley   +1 more source

Imidazole Alkaloids Epiisopilosine and Epiisopiloturine Attenuate Acetaminophen‐Induced Liver Toxicity in Mice via Autophagy Modulation and Anti‐Inflammatory Effects

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 3, March 2026.
Imidazole alkaloids epiisopilosine and epiisopiloturine protect the liver against acetaminophen‐induced toxicity by reducing oxidative stress, suppressing inflammatory mediators, and restoring antioxidant defenses. These hepatoprotective effects are partially mediated by enhanced autophagy, indicating a key mechanistic pathway for the biological ...
Ana Patricia de Oliveira, Gabriella Pacheco, André Luis Fernandes Lopes, Andreza Ketly da Silva Araujo, Letícia de Sousa Chaves, Simone de Araújo, Erick Bryan de Sousa Lima, Even Herlany Pereira Alves, Celso Martins Queiroz‐Junior, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Jéssica Maria Teles Souza, Ayslan Batista Barros, Paulo Sérgio de Araujo Sousa, Jefferson Almeida Rocha, Ana Jérsia Araújo, José Delano Barreto Marinho Filho, Leiz Maria Costa Véras, Daniel Fernando Pereira Vasconcelos, Jand Venes Rolim Medeiros   +19 more
wiley   +1 more source

Store‐and‐Forward Teledermatological Collaboration Between Prisons and University Hospitals in Switzerland

JEADV Clinical Practice, Volume 5, Issue 1, Page 138-143, March 2026.
Dermatological conditions are common but often undertreated, causing unnecessary suffering. Teledermatology offers remote consultations to improve access. Our study analyzed 140 consultations in 125 inmates, mostly male with skin type IV. Itching and pain were frequent symptoms; eczema and scabies were common diagnoses.
Thaadsajini Manivannan, Ephsona Shencoru, Julia Beck, Lukas Schramm, Naomi May Mueller, Elisabeth V. Goessinger, Ralph Braun, Christian Greis   +7 more
wiley   +1 more source

Does Ivermectin Pollute the Surroundings of Swine Farms?

Veterinary Medicine and Science
Pharmaceuticals are emerging environmental pollutants, with macrocyclic lactones like ivermectin raising concerns due to their widespread use and persistence.
Alicia Maria Carrillo Heredero, Elena Butovskaya, Giulia Segato, Luigino Calzetta, Simonetta Menotta, Simone Bertini   +5 more
doaj   +1 more source

Green Synthesis of Metal Oxide Nanoparticles Using Plant Extracts: Applications in Catalysis and Biomedicine

Nano Select, Volume 7, Issue 3, March 2026.
ABSTRACT The green synthesis of metal oxide nanoparticles (MONPs) using plant‐based resources has gained significant traction as an environmentally benign, cost‐effective, and scalable alternative to traditional chemical and physical methods. This review comprehensively explores the plant‐mediated synthesis routes for a variety of MONPs, including CuO,
Faith Mwangi, Jannatun Zia, Ufana Riaz
wiley   +1 more source

Efficacy of acaricides against larvae of Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) and Rhipicephalus (Boophilus) microplus (Canestrini, 1887) (Acari: Ixodidae)

Biotemas, 2017
Parasitism by mites has always been of concern with regard to losses in animal production and to the transmission of etiologic agents of important diseases as well, and about 95% of the developing forms of ticks in the non-parasitic phase are in the ...
Luciano Melo de Souza, Marco Antonio de Andrade Belo, Ives Charlie da Silva   +2 more
doaj  

Transcriptomic Analysis of Tambaqui (Colossoma macropomum) Exposed to Trichlorfon-Induced Toxicity

Animals
Trichlorfon is an antiparasitic agent widely used to control pests and parasites in farmed fish. Tambaqui (C. macropomum) is the most commercially important characid species farmed in the Amazon region.
Hallana Cristina Menezes da Silva, Igor Kelvyn Cavalcante Lobo, André Gentil da Silva, Ana Lúcia Silva Gomes, Wallice Paxiúba Duncan, Juliana Costa Silva, Fabrício M. Lopes, Roberto Ferreira Artoni, Daniele Aparecida Matoso   +8 more
doaj   +1 more source

Trends and Patterns of Adverse Drug Reaction Reporting in Sierra Leone: A Retrospective Analysis of VigiFlow Data (2008–2022)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 3, March 2026.
ABSTRACT Purpose Adverse drug reactions (ADRs) present significant obstacles for healthcare systems, impacting both patient safety and the effectiveness of treatments. Despite this, there is a scarcity of research on ADR reports in Sierra Leone, especially over long periods.
Isatu Jalloh, Onome Thomas Abiri, Peter Bai James, Rajesh Vagiri, Neelaveni Padayachee   +4 more
wiley   +1 more source

Untargeted Metabolomics Reveals Organ‐Specific and Extraction‐Dependent Metabolite Profiles in Endemic Tajik Species Ferula violacea Korovin

Plant Direct, Volume 10, Issue 3, March 2026.
ABSTRACT Ferula violacea Korovin, an endemic Tajikistani plant with purported medicinal properties, remains understudied. This study employs untargeted metabolomics to characterize the metabolite profiles of ethanol extracts and juices from F. violacea roots and seeds.
Sylhiya Mavlonazarova, Kenneth Acosta, Rinat Abzalimov, Saidbeg Satorov, Vyacheslav Dushenkov   +4 more
wiley   +1 more source