Results 211 to 220 of about 27,943 (232)
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Antiphospholipid syndrome, antiphospholipid antibodies, and atherosclerosis
Current Atherosclerosis Reports, 2001The antiphospholipid syndrome is characterized by arterial and venous thrombosis, as well as pregnancy morbidity, in the presence of elevated levels of antiphospholipid antibodies. These autoantibodies have procoagulant activity, as they affect platelets, humoral coagulation factors, and endothelial cells.
Y, Sherer, Y, Shoenfeld
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Antiphospholipid antibodies and the antiphospholipid syndrome
Springer Seminars in Immunopathology, 1994The study of aPL antibodies and the APS has appealed to large numbers of investigators over the last decade. This accounts, in part, for the great degree of apparently contradictory data being published. What seems certain is that these antibodies are associated with thrombosis and recurrent pregnancy loss, and animal data suggest a direct role in ...
E N, Harris, S S, Pierangeli
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Atherogenic Antiphospholipid Antibodies in Antiphospholipid Syndrome
Annals of the New York Academy of Sciences, 2007Abstract: Macrophage uptake of oxidized LDL (oxLDL) plays a critical role in early stages of atherosclerosis. We previously reported that oxLDL forms stable complexes with β2‐glycoprotein I (β2GPI), and that these complexes were frequently present in the sera of patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS ...
Kazuko, Kobayashi +2 more
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Antiphospholipid antibodies, antiphospholipid syndrome and infections
Autoimmunity Reviews, 2008Since the association between antiphospholipid antibodies (aPL) and syphilis was first described, many other viral, bacterial and parasitic infections have been shown to induce antiphospholipid antibodies, notably anticardiolipin antibodies (aCL). A review of the literature shows that while aCL occur frequently in viral infections, particularly in HIV (
Damien, Sène +2 more
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Atherosclerosis, Antiphospholipid Syndrome, and Antiphospholipid Antibodies
Frontiers in Bioscience, 2007In antiphospholipid syndrome (APS) patients, some antiphospholipid antibodies (APA) are directed against negatively-charged phospholipids, while other APA are specific for phospholipid-proteins such as beta2-glycoprotein I (beta2GPI). Increased levels of oxidized low density lipoproteins (oxLDL) are present in atherosclerosis patients and these ...
Danielle, Nicolo +2 more
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Antiphospholipid antibody syndrome
Hematology, 2009Abstract The antiphospholipid antibody syndrome (APS) is defined by the persistent presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism or pregnancy morbidity. Anti-thrombotic therapy is the mainstay of treatment given the high risk of recurrent thromboembolism that characterizes this ...
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JCR: Journal of Clinical Rheumatology, 1997
Although significant progress has been made during the last decade in our knowledge of the antiphospholipid antibodies (aPL), there are two major questions in clinical practice that require further guidelines: Indications for aPL determination and laboratory tests to choose. This article reviews the main clinical indications to search for aPL (systemic
R, Cervera, J, Font, R A, Asherson
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Although significant progress has been made during the last decade in our knowledge of the antiphospholipid antibodies (aPL), there are two major questions in clinical practice that require further guidelines: Indications for aPL determination and laboratory tests to choose. This article reviews the main clinical indications to search for aPL (systemic
R, Cervera, J, Font, R A, Asherson
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Antiphospholipid Antibody Syndromes
Rheumatic Disease Clinics of North America, 1989There is no doubt that in some individuals the presence of antibodies to negatively charged phospholipids currently measured as the lupus anticoagulant, a biologically false positive VDRL, and anticardiolipin antibodies is associated with certain clinical features, in particular, a predisposition to both arterial and venous thrombosis and, in women, to
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Pediatric Antiphospholipid Antibodies and Antiphospholipid Syndrome
Seminars in Thrombosis and Hemostasis, 2008Antiphospholipid syndrome (APS) can occur in children, like adults, with the same diverse spectrum of thrombotic sites but predominately with deep vein thrombosis and stroke. In contrast with adults, however, transient nonthrombogenic antiphospholipid (aPL) antibodies are seen more commonly, usually after childhood infections.
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Noncriteria antiphospholipid antibodies in antiphospholipid syndrome
International Journal of Laboratory HematologyAbstractAntiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombotic manifestations and/or obstetric complications in patients with persistently positive antiphospholipid antibodies (aPL). aPL are a heterogeneous group of autoantibodies, but only lupus anticoagulant, anticardiolipin (aCL), and antibeta2‐glycoprotein I antibodies
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