Results 21 to 30 of about 24,731 (282)
Annals of Noninvasive Electrocardiology, Volume 28, Issue 1, January 2023., 2023 The patient’s ECG exhibited QT‐interval prolongation with T‐wave inversion in anterior and inferior leads that, together with CT‐pulmonary angiography findings, strongly suggested PE. This ECG pattern is crucial for diagnosing PE. Abstract Even though patients with pulmonary embolism usually present with respiratory distress and tachycardia, the ...
Jing‐Xiu Li +3 more
wiley +1 more source
Clinical and Applied Thrombosis/Hemostasis, 2022 The antiphospholipid syndrome (APS), a systemic autoimmune disease characterized by a hypercoagulability associated to vascular thrombosis and/or obstetric morbidity, is caused by the presence of antiphospholipid antibodies such as lupus anticoagulant ...
R Arreola-Diaz MSc +3 more
doaj +1 more source
Systemic lupus erythematosus and cardiovascular disease
Journal of Internal Medicine, Volume 293, Issue 1, Page 48-62, January 2023., 2023 Abstract The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment and care, but cardiovascular disease (CVD) still remains an important clinical problem, since the risk of CVD in SLE is much higher than among controls.
Johan Frostegård
wiley +1 more source
Lysine residues control the conformational dynamics of beta 2-glycoprotein I [PDF]
, 2020 One of the major problems in the study of the dynamics of proteins is the visualization of changing conformations that are important for processes ranging from enzyme catalysis to signaling. A protein exhibiting conformational dynamics is the soluble blood protein beta 2-glycoprotein I (beta2GPI), which exists in two conformations: the closed (circular)
arxiv +1 more source
South African Journal of Radiology, 1997 A brain FDG PET study was performed on a 21-year-old woman with subacute chorea of unknown origin. Associated with her chorea, she had abnormal levels of antiphospholipid antibodies.
M. M. Sathekge +3 more
doaj +1 more source
Gynecology Obstetrics & Reproductive Medicine, 2020 Objective: Obstetric antiphospholipid antibody syndrome is clinically recognized by adverse obstetric outcomes. To determine which antibody level best corresponds to the risk of these clinical outcomes is difficult.
Onder Onen, Fusun Gulizar Varol
doaj +1 more source
Gastrointestinal symptoms as the first manifestation of antiphospholipid syndrome
BMC Gastroenterology, 2021 Background Antiphospholipid syndrome (APS) is an acquired pre-thrombotic autoimmune condition, which produces autoantibodies called antiphospholipid antibodies (APL) against phospholipid-binding plasma proteins. The diagnosis of APS requires at least one
Xiaojuan Zou +5 more
doaj +1 more source
Antibody Watch: Text Mining Antibody Specificity from the Literature [PDF]
PLOS Computational Biology, 2021, 2020 Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading to unreliable research results.
arxiv +1 more source
Antibody Representation Learning for Drug Discovery [PDF]
arXiv, 2022 Therapeutic antibody development has become an increasingly popular approach for drug development. To date, antibody therapeutics are largely developed using large scale experimental screens of antibody libraries containing hundreds of millions of antibody sequences.
arxiv
ASAP-SML: An Antibody Sequence Analysis Pipeline Using Statistical Testing and Machine Learning [PDF]
, 2020 Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of antibodies to their unique properties as inhibitors.
arxiv +1 more source