Results 221 to 230 of about 5,245,251 (341)

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

open access: yesThe FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati   +4 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

open access: yesThe FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard   +4 more
wiley   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

open access: yesHaemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini   +4 more
wiley   +1 more source

Development and Validation of a Prediction Rule for Benefit and Harm of Dual Antiplatelet Therapy Beyond 1 Year After Percutaneous Coronary Intervention.

open access: yesJournal of the American Medical Association (JAMA), 2016
R. Yeh   +15 more
semanticscholar   +1 more source

The Impact of Periodontal Health Interventions on the Risk of Ischemic Stroke: A Systematic Review and Meta‐Analysis

open access: yesInternational Journal of Dental Hygiene, EarlyView.
ABSTRACT Aim To systematically review the evidence on the relationship between periodontal health interventions and the risk of first‐ever ischemic stroke. Materials and Methods Search strategy included electronic and hand searching to January 2025. MEDLINE (OVID), EMBASE (OVID), SCOPUS, LILACS, Web of Science (WOS) and Cochrane Central Register of ...
Jorge Moldes   +7 more
wiley   +1 more source

A Multicenter Propensity Score-Matched Cohort Study of Preoperative Antiplatelet Therapy and Postoperative Outcomes in Elderly Surgical Patients. [PDF]

open access: yesMedicina (Kaunas)
Song S   +16 more
europepmc   +1 more source

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