Results 131 to 140 of about 8,789 (241)

Exogenous Vitamin D Mitigates Salt Stress in Arabidopsis thaliana via Ion Homeostasis and Calcium‐Mediated Signaling

open access: yesPlant Direct, Volume 10, Issue 10, October 2026.
ABSTRACT Understanding the physiological, biochemical, and molecular responses of Arabidopsis thaliana to salt stress and the potential of exogenous vitamin D application to alleviate these responses is critical for developing effective biostimulant strategies under increasing soil salinization.
Busra Özdemirci   +3 more
wiley   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1644-1657, October 2026.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo   +5 more
wiley   +1 more source

Metformin Inhibits Ferroptotic Cell Death by Suppressing Cysteine Deprivation‐Induced Mitochondrial Dysfunction

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic strategy for cancer. Metformin, a widely used biguanide antidiabetic drug, has recently been reported to induce ferroptosis and exert anticancer effects in various malignancies.
Se‐Kyeong Jang   +5 more
wiley   +1 more source

Harnessing halophyte adaptations for salinity resilient agriculture through genetic mechanisms and crop improvement

open access: yesDiscover Plants
Halophytes, constituting approximately 1–2% of global flora, represent a diverse group of salt-tolerant plant species distributed across coastal marshes, mangrove swamps, saline deserts, and inland salt flats.
S. Sasipriya   +4 more
doaj   +1 more source

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

open access: yesCancer Science, Volume 117, Issue 10, Page 2769-2789, October 2026.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei   +9 more
wiley   +1 more source

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 10, Page 1667-1685, October 2026.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu   +5 more
wiley   +1 more source

E3 Ubiquitin Ligases in MASH‐Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities

open access: yesLiver International, Volume 46, Issue 10, October 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a major cause of progressive liver fibrosis and can ultimately lead to cirrhosis and hepatocellular carcinoma (HCC). MASH‐associated liver fibrosis develops through a complex interplay among lipotoxic hepatocyte injury, oxidative and endoplasmic reticulum stress, inflammatory ...
Ah‐Reum Oh   +8 more
wiley   +1 more source

Trypanosomal MICOS Is Assembled on Non‐Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins

open access: yesMolecular Microbiology, Volume 126, Issue 4, Page 396-411, October 2026.
The mitochondrial membrane‐shaping machinery MICOS is assembled surprisingly early during the life cycle of Trypanosoma brucei, before the mitochondrion acquires its mature architecture or full respiratory capacity. Our study also identifies two previously uncharacterized proteins associated with MICOS, providing new insight into the early organization
Michala Boudová   +5 more
wiley   +1 more source

A laser capture microdissection‐based transcriptome analysis on salt glands highlights salt secretion mechanism in mangrove plant Avicennia marina

open access: yesThe Plant Journal, Volume 128, Issue 1, October 2026.
SUMMARY Salt glands, developed in the epidermis of salt‐secreting mangrove plant Avicennia marina leaves and specialized in salt secretion, are critical for improving the survival under high saline habitats. However, the salt secretion mechanism in A. marina remains poorly understood. In this study, laser capture microdissection was employed to isolate
Ming‐Yue Wei   +13 more
wiley   +1 more source

Vibrio cholerae Response to Environmental Factors Including pH and Salt Content in the Absence of Specific Antiporters [PDF]

open access: yes
Vibrio cholerae is a gram-negative gammaproteobacteria, well known for causing the watery-diarrheal disease Cholera. V. cholerae is endemic to the marine and freshwater ecosystems of India and surrounding aquatic environments within that region.
Edwards, Jesse, Payne, Rachel
core   +2 more sources

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