Results 91 to 100 of about 181,112 (317)
Brain networks reveal the effects of antipsychotic drugs on schizophrenia patients and controls [PDF]
arXiv, 2018 The study of brain networks, including derived from functional neuroimaging data, attracts broad interest and represents a rapidly growing interdisciplinary field. Comparing networks of healthy volunteers with those of patients can potentially offer new, quantitative diagnostic methods, and a framework for better understanding brain and mind disorders.
arxiv
Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition
Chemistry &Biodiversity, Accepted Article.Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb +5 more
wiley +1 more source
Functional properties of striatal fast-spiking interneurons
Frontiers in Systems Neuroscience, 2011 Striatal fast-spiking interneurons (FSIs) have a major influence over behavioral output, and a deficit in these cells has been observed in dystonia and Tourette syndrome.
Joshua D Berke
doaj +1 more source
BMC Psychiatry, 2016 BackgroundMost antipsychotics are associated with weight gain and other metabolic complications. Several randomized trials have shown metformin to be effective, but this still hasn’t been included in clinical guidelines on managing antipsychotic induced ...
V. D. de Silva +5 more
semanticscholar +1 more source
Şizofreni tanılı hastalarda metabolik sendrom ve D vitamini düzeyleri ilişkisi
Cukurova Medical Journal, 2019 Amaç: Bu çalışmada şizofreni tanılı hastalarda D vitamini, Pozitif ve Negatif Sendrom Ölçeği skorları, antipsikotik kullanımı ve sosyodemografik verilerin metabolik sendrom ile ilişkisinin gösterilmesi amaçlanmıştır.Gereç ve Yöntem: Retrospektif dosya ...
Mehmet Emin DEMİRKOL +3 more
doaj +1 more source
Effect of antipsychotics on community structure in functional brain networks [PDF]
arXiv, 2018 Schizophrenia, a mental disorder that is characterized by abnormal social behavior and failure to distinguish one's own thoughts and ideas from reality, has been associated with structural abnormalities in the architecture of functional brain networks.
arxiv
A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat [PDF]
arXiv, 2020 Background: In patients with psychotic disorders, sleep spindles are reduced, supporting the hypothesis that the thalamus and glutamate receptors play a crucial etio-pathophysiological role, whose underlying mechanisms remain unknown. We hypothesized that a reduced function of NMDA receptors is involved in the spindle deficit observed in schizophrenia.
arxiv
Molecular Psychiatry, 2018 Antipsychotic drugs are effective interventions in schizophrenia. However, the efficacy of these agents often decreases over time, which leads to treatment failure and symptom recurrence.
D. Amato +14 more
semanticscholar +1 more source
A multi-etiology model of systemic degeneration in schizophrenia [PDF]
arXiv, 2008 We discuss the possibility of multiple underlying etiologies of the condition currently labeled as schizophrenia. We support this hypothesis with a theoretical model of the prefrontal-limbic system. We show how the dynamical behavior of this model depends on an entire set of physiological parameters, representing synaptic strengths, vulnerability to ...
arxiv
Schizophrenia bulletin, 2016 Although weight gain is a serious but variable adverse effect of antipsychotics that has genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of antipsychotic-related weight gain is missing.
J. Zhang +13 more
semanticscholar +1 more source