Results 71 to 80 of about 41,988 (210)

Non-antipsychotic catecholaminergic drugs for antipsychotic-induced tardive dyskinesia

, 2018
Background: Tardive dyskinesia (TD) is a disabling movement disorder associated with the prolonged use of antipsychotic medication. Several strategies have been examined in the treatment of TD.
Rathbone, John, Hanna Bergman, Karla Soares-Weiser, Bergman, Hanna, El-Sayeh, Hany G., Hany G El-Sayeh, El-Sayeh, Hany G, John Rathbone, Soares-Weiser, Karla   +8 more
core   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source

Risk of congenital malformations associated with first-trimester exposure to antipsychotics: A propensity score-weighted population-based cohort study

European Psychiatry
Background There is growing concern regarding teratogenic effect of antipsychotics. Previous research assessing association between antipsychotics and congenital malformations (CMs) yielded mixed results and were all derived from Western countries.
Joe K.N. Chan, Krystal C.K. Lee, Corine S.M. Wong, Wing C. Chang   +3 more
doaj   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Aripiprazole Plasma Concentrations Delivered from Two 2-Month Long-Acting Injectable Formulations: An Indirect Comparison

Neuropsychiatric Disease and Treatment, 2023
Matthew Harlin,1,* Craig Chepke,2,3,* Frank Larsen,4,* Karimah S Bell Lynum,5,* Sanjeda R Chumki,5,* Heather Fitzgerald,6,* Pedro Such,7,* Jessica Madera-McDonough,8,* Murat Yildirim,7,* Moeen Panni,8,* Stephen R ...
Harlin M, Chepke C, Larsen F, Bell Lynum KS, Chumki SR, Fitzgerald H, Such P, Madera-McDonough J, Yildirim M, Panni M, Saklad SR   +10 more
doaj  

Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis [PDF]

, 2000
Objective To develop an evidence base for recommendations on the use of atypical antipsychotics for patients with schizophrenia.Design Systematic overview and meta-regression analyses of randomised controlled trials, as a basis for formal development of ...
Freemantle, Nick, Geddes, J, Freemantle, N, Bebbington, P, Harrison, P, Natl Schizophrenia Guideline Dev   +5 more
core   +1 more source

Environmental impact of antidepressants: Is a new prescription framework possible?

British Journal of Clinical Pharmacology, EarlyView.
Aims Antidepressants such as venlafaxine and sertraline pose high risks to water ecosystems. As depressive disorders and other mental health conditions become increasingly prevalent worldwide, prescription and environmental presence of these pharmaceuticals continue to rise. This study explores the practical viability of a new framework for prescribing
Matilde Bianconi, Valentina Giunchi, Michael Thiede, Elisa Sangiorgi, Marco Menchetti, Elisabetta Poluzzi   +5 more
wiley   +1 more source

Genetic pharmacotherapy as an early CNS drug development strategy: testing glutaminase inhibition for schizophrenia treatment in adult mice

Frontiers in Systems Neuroscience, 2016
Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands.
Susana eMingote, Susana eMingote, Justine eMasson, Justine eMasson, Celia eGellman, Gretchen Miller Thomsen, Gretchen Miller Thomsen, Chyuan-Sheng eLin, Robert J. Merker, Inna eGaisler-Salomon, Inna eGaisler-Salomon, Yvonne eWang, Rachel eErnst, Rene eHen, Rene eHen, Stephen eRayport, Stephen eRayport   +16 more
doaj   +1 more source

Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12-month prospective study

, 2014
Objective: Effects of conventional and atypical antipsychotics on bone mineral density (BMD) and serum prolactin levels (PRL) were examined in patients with schizophrenia.Methods: One hundred and sixty-three first-episode inpatients with schizophrenia ...
Mi, Guolin, Cao, Bingyu, Tang, Maoqin, Jian, Jia, Hou, Ruihua, Qiu, Huimin, Wang, Mengxin   +6 more
core   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source