Results 91 to 100 of about 169,585 (295)

Genetic pharmacotherapy as an early CNS drug development strategy: testing glutaminase inhibition for schizophrenia treatment in adult mice

Frontiers in Systems Neuroscience, 2016
Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands.
Susana eMingote, Susana eMingote, Justine eMasson, Justine eMasson, Celia eGellman, Gretchen Miller Thomsen, Gretchen Miller Thomsen, Chyuan-Sheng eLin, Robert J. Merker, Inna eGaisler-Salomon, Inna eGaisler-Salomon, Yvonne eWang, Rachel eErnst, Rene eHen, Rene eHen, Stephen eRayport, Stephen eRayport   +16 more
doaj   +1 more source

Concomitant medication use and clinical outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder. [PDF]

, 2019
BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is commonly administered to Major Depressive Disorder (MDD) patients taking psychotropic medications, yet the effects on treatment outcomes remain unknown.
Chawla, Shweta A, Cook, Ian A, Hunter, Aimee M, Krantz, David E, Leuchter, Andrew F, Levitt, Jennifer G, Minzenberg, Michael J, Rotstein, Natalie M   +7 more
core   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Spotlight on once-monthly long-acting injectable aripiprazole and its potential as maintenance treatment for bipolar I disorder in adult patients

Neuropsychiatric Disease and Treatment, 2018
Vanessa Torres-Llenza, Pooja Lakshmin, Daniel Z Lieberman Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC, USA Abstract: The lack of long-term medication adherence is
Torres-Llenza V, Lakshmin P, Lieberman DZ   +2 more
doaj  

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study. [PDF]

, 2018
Although individuals at clinical high risk (CHR) for psychosis exhibit a psychosis-risk syndrome involving attenuated forms of the positive symptoms typical of schizophrenia (SZ), it remains unclear whether their resting-state brain intrinsic functional ...
Calhoun, Vince, Chen, Jiayu, Du, Yuhui, Fryer, Susanna, Lin, Dongdong, Loewy, Rachel, Mathalon, Daniel, Stuart, Barbara, Sui, Jing, Yu, Qingbao   +9 more
core   +2 more sources

Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment‐Naive Patients Compared With Zoledronate

Clinical Pharmacology &Therapeutics, EarlyView.
We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu, Shiow‐Ing Wang, Shun‐Fa Yang   +2 more
wiley   +1 more source

Dosing strategies for switching from oral risperidone to paliperidone palmitate: Effects on clinical outcomes. [PDF]

, 2017
IntroductionThere are currently no guidelines for switching patients from oral risperidone to paliperidone palmitate (Invega Sustenna®). Furthermore, the paliperidone long-acting injectable (LAI) package insert does not recommend bridging with oral ...
Hsia, Stephanie L, Jackson, Elizabeth, Lacro, Jonathan P, Leckband, Susan G, Rao, Sanjai   +4 more
core   +2 more sources

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source