Results 141 to 150 of about 106,790 (296)

Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors

ChemistryOpen, EarlyView.
This work investigates the selective inhibition of MAO enzymes by varying the substitution of electron‐withdrawing and donating groups on the phenyl rings of tetrahydropyridines (4 a–4 o). Compounds 4 l and 4 n exhibit promising IC50 values of 0.40±0.05 and 1.01±0.03 μM against MAO‐A and MAO‐B, respectively.
Obaid ur Rehman Khan, Bilal Ahmad Khan, Syeda Shamila Hamdani, Saquib Jalil, Peter A. Sidhom, Khalid Elfaki Ibrahim, Tarad Abalkhail, Jamshed Iqbal, Hatem Tallima, Tamer Shoeib, Mahmoud A. A. Ibrahim   +10 more
wiley   +1 more source

Antipsychotic Polypharmacy, Part 1: Therapeutic Option or Dirty Little Secret?

, 1999
Stephen M. Stahl
openalex   +2 more sources

Discrepancies on prescribing antipsychotics [PDF]

, 1995
Sonia Dollfus, Jim van Os, M. Petit
openalex   +1 more source

Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications

ChemistryOpen, EarlyView.
This review highlights the emerging applications of molecularly imprinted polymers (MIPs) in bone regeneration and diagnosis. MIPs facilitate osteogenic treatments by guiding stem cell differentiation and delivering bioactive molecules and enable precise detection of bone turnover biomarkers via MIP‐based sensors, offering promising strategies for next‐
Ren Yang, Xiaohan Ma, Mingcheng Xuan, Yingqi Ma, Jiexian Ding, David Y. S. Chau, Jonathan C. Knowles, Feng Peng, Alessandro Poma   +8 more
wiley   +1 more source

The antipsychotics functional index (AFI) in schizophrenia. [PDF]

Front Pharmacol
Marinescu GC, Ifteni PI, Teodorescu A, Georgescu R.   +3 more
europepmc   +1 more source

Metabolites of the antipsychotic agent clozapine inhibit the replication of human immunodeficiency virus type 1

, 1997
Lorraine Jones‐Brando, James L. Buthod, L E Holland, Robert H. Yolken, E. Fuller Torrey   +4 more
openalex   +1 more source

Anterior Cingulate Cortex Glutamate Levels and Sensory Integration Are Associated in Individuals With Social Anhedonia: A Comparison Between 3T and 7T MRS

PsyCh Journal, EarlyView.
ABSTRACT Deficits in schizophrenia are linked to abnormalities in the glutamate (Glu) system, which are believed to result in neurological soft signs (NSS) and negative symptoms. This study investigated the relationship between Glu levels of the anterior cingulate cortex (ACC) and NSS, particularly sensory integration, in individuals with high and low ...
Yun‐Ru Wang, Xuan Wang, Xin‐Lu Cai, Ling‐Ling Wang, Yu‐Xi Zhao, Li‐Xian Wang, Wei Mao, Zhu‐Jun Wei, Fangrong Zong, Yi Wang, Simon S. Y. Lui, Rong Xue, Raymond C. K. Chan   +12 more
wiley   +1 more source

Maintenance of antipsychotic efficacy with Amisulpride: Results of a long-term study versus haloperidol [PDF]

, 1998
L Colonna, W. Rein, S. Turjanski
openalex   +1 more source

Evaluation of the Drug–Drug Interaction Potential of the GlyT1 Inhibitor Iclepertin (BI 425809): A Physiologically Based Pharmacokinetic (PBPK) Modeling Approach

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Despite predicting poor functional outcomes and being a significant patient burden, there are no approved pharmacotherapies to treat symptoms of cognitive impairment associated with schizophrenia (CIAS). Iclepertin (BI 425809) is a potent and selective inhibitor of glycine transporter‐1 (GlyT1) that was in Phase III development for the ...
Elin M. Matsson, Michael Desch, Valerie Nock, Nina Hanke   +3 more
wiley   +1 more source

A cross-sectional survey of sexual dysfunction in patients taking antipsychotic medication [PDF]

, 1998
Sue Smith, P. Mostyn, S. Vernals, Veronica O’Keane, Robin Murray   +4 more
openalex   +1 more source