Results 41 to 50 of about 106,790 (296)
Alternative initiation regimen of paliperidone palmitate long-acting injectable
European Psychiatry, 2022 Introduction Long-acting injectable antipsychotics (LAIs) hold an important place in the treatment of psychosis. Knowledge of the best way to administer LAIs is important to maximize the efficacy and minimize the side-effects Objectives To assess the ...
I.E. Menendez Gil +2 more
doaj +1 more source
Angewandte Chemie International Edition, Accepted Article.This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley +1 more source
Physical activity in schizophrenia is higher in the first episode than in subsequent ones
Frontiers in Psychiatry, 2015 Schizophrenia is frequently associated with abnormal motor behavior, particularly hypokinesia. The course of the illness tends to deteriorate in the first years.
Sebastian eWalther +5 more
doaj +1 more source
Effectiveness of antipsychotics in schizophrenia with comorbid substance use disorder
European Psychiatry, 2021 Introduction Schizophrenia is highly comorbid with substance use disorders (SUD), which may negatively impact the course of illness. However, large studies exploring the best lines of treatment for this combination are lacking.
M. Lähteenvuo +6 more
doaj +1 more source
Autism Research, EarlyView.ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham‐controlled, double‐blind parallel‐group Phase‐
Christina Luckhardt +18 more
wiley +1 more source
Management of antipsychotic-related sexual dysfunction
European Psychiatry, 2022 Introduction Sexual dysfunction (SD) can often be a side-effect of treatment with antipsychotics (APS). It often jeopardizes long-term adherence to treatment, while deeply affecting the patient’s quality of life.
C. Rodrigues
doaj +1 more source
Focus, 2020 Physicians who treat patients with schizophrenia frequently encounter complex clinical situations not fully addressed by published treatment guidelines. Some of these situations lead to antipsychotic polypharmacy, often prescribed when clinical and social obstacles prevent access to clozapine and patients have had suboptimal responses to nonclozapine ...
Adriana, Foster, Jordanne, King
openaire +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Jens Andreas Sarömba +9 more
wiley +1 more source
The (ANTI)psychotic paradox: Lewy body dementia
European Psychiatry, 2021 Introduction Lewy Bodie Dementia (LBD) is the second more common progressive dementia caused by the deposition of proteins at the neocortical level, producing motor and psychotic symptoms (parkinsonism and visual hallucinations) which typically get ...
J. Galvañ, I. Angélico
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Deprescribing is complex because it involves patients' health, values, and preferences. The World Health Organization and Canadian Medication Appropriateness and Deprescribing Network have recommended that deprescribing be integrated into health curricula, prompting the need for further understanding about deprescribing education.
Brian J. Chow +3 more
wiley +1 more source