Results 41 to 50 of about 195,206 (338)
Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse. [PDF]
, 2017 Current antipsychotic medications used to treat schizophrenia all target the dopamine D2 receptor. Although these drugs have serious side effects and limited efficacy, no novel molecular targets for schizophrenia treatment have been successfully ...
Boutros, PC +5 more
core +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Frontiers in PsychiatryBackgroundOptimal use of psychotropic medications for people living with dementia is important. By finding potentially modifiable factors, dementia care teams may find solutions to achieve the appropriate use of psychotropic drugs.ObjectiveThis study ...
Wei-Chieh Chan +5 more
doaj +1 more source
A Study to Assess the Therapeutic Effect of Enalapril on Olanzapine Induced Metabolic Syndrome in Wistar Rats [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Metabolic Syndrome (MS) is a complex of risk factors for the development of cardiovascular complications and Type 2 Diabetes Mellitus (DM). Pharmacological management of the condition is complex, as multiple drug groups have to be used,
Avinash Arivazhahan +3 more
doaj +1 more source
Advanced Science, EarlyView.A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen +15 more
wiley +1 more source
Treatment of early onset schizophrenia: Recent trends, challenges and future considerations
Frontiers in Psychiatry, 2012 Early onset schizophrenia (onset before adulthood) is a rare, severe and chronic form of schizophrenia. Antipsychotic treatment remains the mainstay of treatment although current medications provide suboptimal response at best.
Nora S Vyas, Nitin eGogtay
doaj +1 more source
Quality of life in Romanian patients with schizophrenia based on gender, type of schizophrenia, therapeutic approach, and family history [PDF]
, 2018 The low quality of life of patients with schizophrenia has been extensively discussed and investigated. Various aspects from gender, socio-demographic profile, and/or type of neuroleptic treatment have been taken into account in describing this condition.
Alexinschi, Ovidiu Eugen +4 more
core +3 more sources
MRI Epicenters Differentiate Spatiotemporal Patterns of Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.A connectivity‐based MRI epicenter model identifies two Parkinson's disease subtypes: subtype 1 with infratentorial‐dominant epicenters, severe motor symptoms, and rapid progression; and subtype 2 with supratentorial‐dominant epicenters with mild progression.
Xiaojie Duanmu +23 more
wiley +1 more source