Results 81 to 90 of about 195,206 (338)
Methylation age acceleration does not predict mortality in schizophrenia. [PDF]
, 2019 Schizophrenia (SCZ) is associated with high mortality. DNA methylation levels vary over the life course, and pre-selected combinations of methylation array probes can be used to estimate "methylation age" (mAge). mAge correlates highly with chronological
Burrage, Joe +7 more
core +1 more source
Antipsychotic combinations for schizophrenia [PDF]
Cochrane Database of Systematic Reviews, 2017 Many people with schizophrenia do not achieve a satisfactory treatment response with their initial antipsychotic drug treatment. Sometimes a second antipsychotic, in combination with the first, is used in these situations.To examine whether:1. treatment with antipsychotic combinations is effective for schizophrenia; and2.
Santiago Castiello-de Obeso +5 more
openaire +5 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre +9 more
wiley +1 more source
Recovery and serious mental illness: a review of current clinical and research paradigms and future directions [PDF]
, 2017 Introduction: Recovery from serious mental illness has historically not been considered a likely or even possible outcome. However, a range of evidence suggests the courses of SMI are heterogeneous with recovery being the most likely outcome. One barrier
Hamm, Jay A. +6 more
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacogenomics enables the personalization of drug therapy by linking genetic variations to differences in drug metabolism, efficacy, and risk of adverse reactions. Genetic polymorphisms within cytochrome P450 (CYP) genes significantly affect enzyme activity, influencing drug plasma levels, responses, and safety.
Alex J. Coulter +4 more
wiley +1 more source
Perspectives on Precision Psychiatry Using Antipsychotics in the Management of Bipolar Disorder
Brain SciencesBackground/Objectives: Precision medicine is not just hype. Instead, it represents a high bar for developing more effective, safer, and better-tolerated therapies in medicine, without exception in psychiatry, including bipolar disorder (BD). A burgeoning
Michele Fornaro +5 more
doaj +1 more source
Chlorpromazine induced priapism from a single dose: an unusual complication of antipsychotic agent
Russian Open Medical Journal, 2017 Priapism is considered as an unusual andrological emergency that requires urgent intervention. It is defined as prolonged penile erection (usually painful) for more than 4 hours not related to sexual excitation or stimulation.
Mohamed Ahmed Abd El Salam, Hisham Foaad
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Inhibition of the oncogenic channel Kv10.1 by the antipsychotic drug penfluridol
Frontiers in PharmacologyDrug repurposing is an increasingly recognized strategy in pharmaceutical development that focuses on identifying new therapeutic uses for already approved drugs, as an alternative to the time-consuming and costly process of developing new molecular ...
Paulina León-Sánchez +7 more
doaj +1 more source