Results 1 to 10 of about 11,448 (254)

Polymorphism and Phase-Transition Thermodynamic Properties of Phenazone (Antipyrine) [PDF]

Molecules
In this work, detailed information on the phase-transition thermodynamics of the analgesic and antipyretic drug phenazone, also known as antipyrine, is reported. It was found that the compound forms two polymorphs. Fusion thermodynamics of both forms was
Dmitrii N. Bolmatenkov, Ilyas I. Nizamov, Andrey A. Sokolov, Airat A. Notfullin, Boris N. Solomonov, Mikhail I. Yagofarov   +5 more
doaj   +2 more sources

Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors.
Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed   +11 more
doaj   +2 more sources

Placental transfer of tofacitinib in the ex vivo dual-side human placenta perfusion model [PDF]

Current Research in Toxicology
Tofacitinib is a small molecule Janus kinase (JAK) inhibitor, introduced to the European market in 2017, for the treatment of rheumatoid arthritis, psoriatic arthritis and ulcerative colitis.
Gaby A.M. Eliesen, Milou Fransen, Hedwig van Hove, Petra H.H. van den Broek, Rick Greupink   +4 more
doaj   +2 more sources

Metamizole does not affect fracture healing in a murine ischemia model [PDF]

Frontiers in Physiology
Metamizole is a commonly used analgesic drug in clinical fracture management, which does not affect the healing process under physiological conditions.
Christian Schönbeck, Janine Stutz, Sebastian T. Schreiber, Lukas Keller, Chiara Siep, Wolfgang Metzger, Mario Giorgi, Irene Sartini, Tobias Fritz, Tim Pohlemann, Michael D. Menger, Emmanouil Liodakis, Matthias W. Laschke, Marcel Orth   +13 more
doaj   +2 more sources

Ecological multivariate assisted spectrophotometric methods for determination of antipyrine and benzocaine HCl in presence of antipyrine official impurity and benzocaine HCl degradant: toward greenness and whiteness [PDF]

BMC Chemistry
A simple and green chemometrics-assisted spectrophotometric technique has beendeveloped and validated for the determination of antipyrine (ANT) and benzocaine HCl (BEN) along with the official impurity of ANT, antipyrine impurity A (ANT imp-A), and the ...
Khadiga M. Kelani, Maha A. Hegazy, Amal M. Hassan, Ahmed H. Nadim   +3 more
doaj   +2 more sources

Iodine(I) pnictogenate complexes as Iodination reagents [PDF]

Communications Chemistry
Halogen(I) complexes are widely used as halogenation reagents and traditionally feature homoleptic stabilising Lewis bases, though the recent revitalisation of iodine(I) carboxylate chemistry has provided isolable examples of heteroleptic iodine(I ...
Sharath Mohan, Kari Rissanen, Jas S. Ward   +2 more
doaj   +2 more sources

N-(3-Cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2-[[5-[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide

Molbank, 2021
The small pyrazolone-bearing molecules attract attention and are widely explored in drug design as pharmacological agents. The new pyrazolone-thiadiazole hybrid molecule N-(3-cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2-[[5-[(1,5-dimethyl-3-oxo-2 ...
Serhii Holota, Ihor Yushyn, Dmytro Khyluk, Renata Vynnytska, Roman Lesyk   +4 more
doaj   +1 more source

Defect State Modulation of TiO2 Nanostructures for Photocatalytic Abatement of Emerging Pharmaceutical Pollutant in Wastewater Effluent

Advanced Energy & Sustainability Research, 2022
Rapid industrialization has resulted in a significant presence of pharmaceutical compounds in aqueous effluents, and therefore, effluents must be effectively treated before discharging them to water bodies.
Prasenjit Kar, Deepanshu Aggarwal, Komal Shukla, Raju Kumar Gupta   +3 more
doaj   +1 more source

UJI EFEKTIFITAS SINBIOTIK KEFIR TEPUNG PISANG BATU TERHADAP KADAR GLUKOSA DARAH DAN KADAR PROFIL LIPID TIKUS MODEL SINDROM METABOLIK Effectiveness Test of banana (Musa balbisiana) Flour Kefir Synbiotic on Blood Glucose Level and Lipid Profile Level in Metabolic Syndrome Rats Model

Media Gizi Indonesia, 2021
Metabolic Syndrome is a metabolic disorder characterized by hyperglycemia, hypertriglyceridemia, and dyslipidemia which can be repaired through synbiotics.
Taufik Maryusman, Christine Diane Dien, Santi Herlina Mail   +2 more
doaj   +1 more source

Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450

Brazilian Journal of Medical and Biological Research, 2002
The present study investigates the isoform(s) of cytochrome P450 (CYP) involved in the metabolism of albendazole sulfoxide (ASOX) to albendazole sulfone (ASON) in patients with neurocysticercosis using antipyrine as a multifunctional marker drug.
M.P. Marques, O.M. Takayanagui, V.L. Lanchote   +2 more
doaj   +1 more source