Results 41 to 50 of about 11,448 (254)

Weak hydrogen bonding in the structures of three double‐acylated aminoantipyrines

Acta Crystallographica Section C, Volume 81, Issue 12, Page 687-693, December 2025.
The structures of three doubly‐acylated 4‐aminoantipyrine compounds where the aryl substituent is varied are reported and analysed in terms of their relative conformation, intermolecular interactions and overall packing. The compounds were crystallized using the encapsulated nanodroplet crystallization (ENaCt) protocol.The structures of three doubly ...
Lina Mardiana, Afnan B. Al Abdali, Michael J. Hall, Hamad H. Al Mamari, Paul G. Waddell   +4 more
wiley   +1 more source

Antimicrobial Potency and E. coli β-Carbonic Anhydrase Inhibition Efficacy of Phenazone-Based Molecules

Molecules, 2023
In this investigation, 4-antipyrinecarboxaldhyde was reacted with methyl hydrazinecarbodithioate to afford the carbodithioate derivative 3. The as-prepared carbodithioate derivative 3 is considered to be a key molecule for the preparation of new ...
Huda R. M. Rashdan, Gharieb S. El-Sayyad, Ihsan A. Shehadi, Aboubakr H. Abdelmonsef   +3 more
doaj   +1 more source

Convergent Recruitment of Cerebellar Purkinje Cells by Mechanistically Diverse General Anesthetics

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
General anesthetics induce reversible unconsciousness; however, their underlying neural mechanisms remain unclear. Using active‐neuron whole‐hemisphere labeling, tissue clearing, and light‐sheet microscopy, we mapped the neurons commonly activated by three mechanistically distinct anesthetics in adult mice.
Nozomi Utsumi, Daisuke H. Tanaka, Ayaka Nakai, Shizuki Inaba, Shigenori Nonaka, Shigeru Maeda, Naofumi Uesaka   +6 more
wiley   +1 more source

Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory Effects

ChemMedChem, Volume 20, Issue 21, November 6, 2025.
Pyrrolidine‐type naphthalene‐2‐acetamide compound 5i inhibits Kelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid 2‐related factor 2 (Nrf2) protein–protein interaction by binding to the Keap1‐DC domain; it subsequently activates intracellular Nrf2 and induces Nrf2‐target genes.
Daisuke Yasuda, Kai Toyoshima, Koujin Kojima, Hanako Ishida, Kazuma Kaitoh, Riyo Imamura, Kayoko Kanamitsu, Hirotatsu Kojima, Megumi Funakoshi‐Tago, Masanori Osawa, Tomoyuki Ohe, Tomoya Hirano   +11 more
wiley   +1 more source

Mitigation of corrosion of carbon steel in acid medium using some antipyrine derivatives

Zaštita Materijala, 2017
Adsorption and inhibition efficiency of some antipyrine derivatives on the C-steel (CS) in 1M HCl were estimated using three electrochemical techniques (electrochemical impedance spectroscopy (EIS), electrochemical frequency modulation (EFM) and ...
Salam Abd Samar A. El, Maksoud Abd Samar A. El   +1 more
doaj   +1 more source

Serum Metabolomics of Patients with Hepatic Cystic Echinococcosis

Biomedical Chromatography, Volume 39, Issue 10, October 2025.
ABSTRACT Hepatic cystic echinococcosis (HCE), a liver manifestation of hydatid disease, is among the 17 neglected tropical diseases (NTDs) prioritized by the WHO for eradication by 2025. Although imaging and serological tests are currently the main diagnostic approaches for HCE, they have notable limitations in sensitivity and specificity.
Yisimayili Aimaiti, Kahaer Tuerxun, Yuan‐Quan Wu, Abudoukeyimu Yasheng, Irshat Ibrahim, Qi‐Lin Xu, Muzaipaer Muhetajiang, Tuerganaili Aji   +7 more
wiley   +1 more source

Copper(II) Complexes with Ligands Derived from 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one: Synthesis and Biological Activity

Molecules, 2006
The synthesis of Cu(II) complexes derived from Schiff base ligands obtainedby the condensation of 2-hydroxybenzaldehyde or terephtalic aldehyde with 4-amino-antipyrine (4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) is presented.
Raluca Cernat, Carmen Chifiriuc, Veronica Lazar, Simona Pasculescu, Tudor Rosu   +4 more
doaj   +1 more source

Sensitive Quantitation of Residual Phenylhydrazine in Antipyrine by LC-ICP-MS with Iodo Derivatization

Analytical Sciences, 2014
Phenylhydrazine is a genotoxic impurity commonly used as a raw material in active pharmaceutical ingredients. In this study, a novel method, using inductively coupled plasma-mass spectrometry combined with two-dimensional liquid chromatography (LC-ICP-MS)
Koki Harigaya, Hiroyuki Yamada, S. Horimoto, H. Nishi, J. Haginaka   +4 more
semanticscholar   +1 more source

Multienzyme (3‐in‐1)‐Mimicking a Single Nucleobase‐Derived Bionanozyme for Versatile Environmental and Biomedical Applications

Advanced Healthcare Materials, Volume 14, Issue 24, September 18, 2025.
This study reports the development of bioinspired 2D crystalline Bionanozyme derived from a single nucleobase. It effectively mimics multienzyme activity to detect and remove phenolic pollutants, identify disease biomarkers with high sensitivity, and protect cells from oxidative stress.
Subrat Vishwakarma, Om Shanker Tiwari, Durba Banerjee, Linda J. W. Shimon, Amit Israelstam, Ilia Kaminker, Sudip Mukherjee, Ehud Gazit, Pandeeswar Makam   +8 more
wiley   +1 more source

Enzymatic assay for cholesterol ester hydrolase activity.

Journal of Lipid Research, 1978
A rapid and accurate method is described for the assay of cholesterol ester hydrolase (CEH) activity. Aliquots of the enzyme-substrate incubation mixture are extracted into isopropanol.
L L Gallo, R Atasoy, G V Vahouny, C R Treadwell   +3 more
doaj   +1 more source