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First Purification of the Antiquitin Protein and Demonstration of Its Enzymatic Activity

FEBS Letters, 2002
Antiquitin is an evolutionarily conserved protein believed to play a role in the regulation of cellular turgor. Based on sequence analysis, this protein is classified as a member of the aldehyde dehydrogenase superfamily. All previous studies on antiquitin have been confined to the nucleotide level, and the protein has never been purified and ...
Christopher Cheng, Wing-Ping Fong
exaly   +3 more sources

Glial Localization of Antiquitin: Implications for Pyridoxine-Dependent Epilepsy [PDF]

Annals of Neurology, 2014
ObjectiveA high incidence of structural brain abnormalities has been reported in individuals with pyridoxine‐dependent epilepsy (PDE). PDE is caused by mutations inALDH7A1, also known as antiquitin. How antiquitin dysfunction leads to cerebral dysgenesis is unknown.
Si Houn Hahn, Sidney M Gospe, Laura A Jansen   +2 more
exaly   +3 more sources

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Antiquitin, a Relatively Unexplored Member in the Superfamily of Aldehyde Dehydrogenases With Diversified Physiological Functions

Cellular and Molecular Life Sciences, 2006
Antiquitin is a member of the aldehyde dehydrogenase superfamily. Sequence analyses indicate that the protein is highly conserved from plants to animals. The plant antiquitins are generally believed to play a role in osmoregulation and/or detoxification.
Christopher Cheng
exaly   +3 more sources

Human Antiquitin: Structural and Functional Studies

Chemico-Biological Interactions, 2011
Antiquitin (ALDH7) is a member of the aldehyde dehydrogenase superfamily which oxidizes various aldehydes to form the corresponding carboxylic acids. Human antiquitin (ALDH7A1) is believed to play a role in detoxification, osmoregulation and more specifically, in lysine metabolism in which alpha-aminoadipic semialdehyde is identified as the specific ...
Wing-Ping Fong
exaly   +3 more sources

Is antiquitin a mitochondrial Enzyme?

Journal of Cellular Biochemistry, 2009
AbstractAntiquitin is an aldehyde dehydrogenase involved in the catabolism of lysine. Mutations of antiquitin have been linked with the disease pyridoxine‐dependent seizures. While it is well established that lysine metabolism takes place in the mitochondrial matrix, evidence for the mitochondrial localization of antiquitin has been lacking.
Judy Wei-Yan, Wong, Chi-Lung, Chan, Wai-Kwan, Tang, Christopher Hon-Ki, Cheng, Wing-Ping, Fong   +4 more
openaire   +2 more sources

Structural and mutational analysis of antiquitin as a candidate gene for Menière disease

American Journal of Medical Genetics, 2002
Published in American Journal of Medical Genetics.
Lynch, M., Cameron, T., Knight, M., Kwok, T., Thomas, P., Forrest, S., Giersch, A., Briggs, R., Pyman, B.   +8 more
openaire   +3 more sources

Pyridoxine‐dependent epilepsy due to antiquitin deficiency: achieving a favourable outcome

Epileptic Disorders, 2013
ABSTRACT We report 4 pyridoxine‐dependent epilepsy patients in which good outcome was determined in three. The 4 patients were male and aged from 7 to 24 years old (from three unrelated Caucasian families). A clinical diagnosis of neonatal pyridoxine‐dependent epilepsy was confirmed by biochemical and genetic studies.
Oliveira, R., Pereira, C., Rodrigues, F., Alfaite, C., Garcia, P., Robalo, C., Fineza, I., Goncalves, O., Struys, E.A., Salomons, G.S., Jakobs, C.A.J.M., Diogo, L.   +11 more
openaire   +3 more sources

Purification, N-Terminal Sequence Determination and Enzymatic Characterization of Antiquitin From the Liver of Grass Carp

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2003
Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes catalyzing the conversion of various aldehydes to the corresponding acids using the coenzymes NAD+ or NADP+. While mammalian ALDHs have been studied extensively, the non-mammalian ALDHs, notably those of teleostean origin, remain relatively unexplored.
Christopher Cheng, Wing-Ping Fong
exaly   +3 more sources

Ectopic Expression of BrALDH7B2 Gene Encoding an Antiquitin From Brassica rapa Confers Tolerance to Abiotic Stresses and Improves Photosynthetic Performance Under Salt Stress in Tobacco

Environmental and Experimental Botany, 2020
Abstract Improved plant performance under salt and drought stresses has been a challenging task to the plant due to the complexity and multitude of genes that govern them. We describe here, isolation and characterization of an aldehyde dehydrogenase gene (BrALDH7B2) that encodes an antiquitin isolated from Brassica rapa.
Rajesh Kumar Meena, Ranjana Gautam, Nyanthanglo Woch   +2 more
exaly   +2 more sources

Pyridoxine-dependent epilepsy owing to antiquitin deficiency — mutation in theALDH7A1gene

Paediatrics and International Child Health, 2013
Pyridoxine-dependent epilepsy (PDE) is an inborn error of metabolism resulting from antiquitin deficiency. There is marked elevation of α-amino adipic semi-aldehyde (αAASA), piperidine-6-carboxylate (P6C) and pipecolic acid. The diagnosis can be confirmed by identifying the mutation in the ALDH7A1 gene in chromosome 5q3l.
Jagadeesh, S., Suresh, B., Murugan, V., Suresh, S., Salomons, G.S., Struys, E.A., Jacobs, C.   +6 more
openaire   +4 more sources