Results 241 to 250 of about 139,558 (270)
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Intensification of Antiretroviral Therapy
AIDS Research and Human Retroviruses, 2001ALTHOUGH IMPORTANT DEVELOPMENTS in antiretroviral treatment have occurred, the ability to durably suppress HIV replication is still quite limited. Current guidelines recommend the introduction of at least two compounds not included in the discontinued regimen for treatment failures.1–3 This approach is based on the assumption that resistance mutations ...
Marina Núñez +2 more
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Clinics in Podiatric Medicine and Surgery, 1998
The use of a combination of more potent antiretroviral agents has resulted in suppression of HIV replication to undetectable levels in many patients. Three classes of antiretroviral drugs are currently available: nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors.
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The use of a combination of more potent antiretroviral agents has resulted in suppression of HIV replication to undetectable levels in many patients. Three classes of antiretroviral drugs are currently available: nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors.
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Journal of the American Academy of Dermatology, 1989
Research into the biology of human immunodeficiency virus type 1 (HIV-1), the causative agent of the acquired immunodeficiency syndrome, has yielded valuable information about the replicative cycle of the virus. The steps involved are (1) attachment of the virus to a receptor protein on the surface of the target cell, (2) entry of the virus into the ...
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Research into the biology of human immunodeficiency virus type 1 (HIV-1), the causative agent of the acquired immunodeficiency syndrome, has yielded valuable information about the replicative cycle of the virus. The steps involved are (1) attachment of the virus to a receptor protein on the surface of the target cell, (2) entry of the virus into the ...
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Pharmacogenetics of antiretroviral therapy
Expert Opinion on Drug Metabolism & Toxicology, 2014Human genetic testing is rapidly entering into most medical disciplines, mainly as a way to predict hereditary conditions including predisposition to cancers or degenerative diseases. Another area of interest for human genomics is to ascertain the therapeutic effect and prevent potential toxicities and/or drug-drug interactions of medication.Several ...
Pablo Labarga +4 more
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Advances in antiretroviral therapy
Current Opinion in HIV and AIDS, 2013To review recent data about advances in ART.In the last 2 years, clinical trials have demonstrated the safety and efficacy of three integrase transfer inhibitors [raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG)], one new nonnucleoside reverse transcriptase inhibitor [rilpivirine (RIL)] and a new extended release formulation of nevirapine ...
Jose R. Arribas, Joseph J. Eron
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Archives of Pharmacal Research, 2000
As we enter the new millennium, there have been dramatic improvements in the care of patients with HIV infection. These have prolonged life and decreased morbidity and mortality. There are fourteen currently available antiretrovirals approved in the United States for the treatment of this infection.
Rafik Samuel, Byungse Suh
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As we enter the new millennium, there have been dramatic improvements in the care of patients with HIV infection. These have prolonged life and decreased morbidity and mortality. There are fourteen currently available antiretrovirals approved in the United States for the treatment of this infection.
Rafik Samuel, Byungse Suh
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Pediatric antiretroviral therapy
Expert Review of Anti-infective Therapy, 2010The rate of perinatal HIV transmission has decreased significantly in developed countries. However, worldwide, it remains the main source of HIV infection within the pediatric population. Recent advances as a result of findings from clinical trials, viral resistance testing and the advent of new drugs have increased the options for initial treatment ...
Adriana Cadilla +2 more
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Antiretroviral Therapy With Heart
American Journal of Therapeutics, 2009Antiretroviral therapy (ART) has resulted in a substantial improvement in the morbidity and mortality associated with human immunodeficiency virus (HIV) infection. As this population ages, cardiovascular disease is becoming an increasingly important health burden.
Paul Randell, Graeme Moyle
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The pharmacogenetics of antiretroviral therapy
Current Opinion in HIV and AIDS, 2006Although the past 20 years have seen many advances in HIV pharmacotherapy, host variability has only been more recently recognized as an important driver of both treatment response and toxicity. This review will focus on the importance of variability in drug metabolizing enzymes and the potential research and clinical applications of these findings in ...
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Update on antiretroviral therapy
Archives of Disease in Childhood, 2009Combination antiretroviral treatment (cART) has been highly successful in preventing mother to child transmission of human immunodeficiency virus (HIV) and in reducing mortality and morbidity in HIV infected children. cART is now recommended for all HIV infected infants and selected older children.
Tamara Bugembe, Andrew Riordan
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