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The pharmacogenetics of antiretroviral therapy
Current Opinion in HIV and AIDS, 2006Although the past 20 years have seen many advances in HIV pharmacotherapy, host variability has only been more recently recognized as an important driver of both treatment response and toxicity. This review will focus on the importance of variability in drug metabolizing enzymes and the potential research and clinical applications of these findings in ...
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Update on antiretroviral therapy
Archives of Disease in Childhood, 2009Combination antiretroviral treatment (cART) has been highly successful in preventing mother to child transmission of human immunodeficiency virus (HIV) and in reducing mortality and morbidity in HIV infected children. cART is now recommended for all HIV infected infants and selected older children.
A, Riordan, T, Bugembe
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Adhering to Antiretroviral Therapies
AIDS Patient Care and STDs, 2001In 1999, the AIDS program conducted a survey of more than 1,000 patients in Sao Paulo [Brazil]. It found that 69 percent achieved 80 percent adherence, which means they took their medicine properly 80 percent of the time. According to Margaret Chesney, a professor of medicine at the University of California at San Francisco who studies behavioral ...
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Archives of Pharmacal Research, 2000
As we enter the new millennium, there have been dramatic improvements in the care of patients with HIV infection. These have prolonged life and decreased morbidity and mortality. There are fourteen currently available antiretrovirals approved in the United States for the treatment of this infection.
R, Samuel, B, Suh
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As we enter the new millennium, there have been dramatic improvements in the care of patients with HIV infection. These have prolonged life and decreased morbidity and mortality. There are fourteen currently available antiretrovirals approved in the United States for the treatment of this infection.
R, Samuel, B, Suh
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Overview of Antiretroviral Therapy
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1994All of the agents that are available for the treatment of human immunodeficiency viral infection belong to the class of drugs called nucleoside analogs that act on the virus's reverse transcriptase enzyme. As their use expanded for increasing cohorts of patients and stages of disease, it became clear that additional agents were required that would act ...
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Combination antiretroviral therapy
Expert Opinion on Pharmacotherapy, 2011Combination antiretroviral therapy (cART) was one of the greatest achievements in medicine in the twentieth century. It has rapidly evolved during the last 10 years from suboptimal monotherapy to an effective triple therapy that can change the natural history of HIV-1 infection from a deadly disease to a chronic, manageable condition.
Pere, Domingo, Francesc, Vidal
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Pediatric Antiretroviral Therapy
2019Human immunodeficiency virus (HIV) is one of the most serious pediatric infectious diseases, affecting around 3 million children and adolescents worldwide. Lifelong antiretroviral treatment (ART) provides multiple benefits including sustained virologic suppression, restoration and preservation of immune function, decreased morbidity and mortality, and ...
Sahera, Dirajlal-Fargo +2 more
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Protein Binding in Antiretroviral Therapies
AIDS Research and Human Retroviruses, 2003There is marked variability in the extent to which the three classes of antiretroviral (ARV) drugs bind to plasma proteins (99%). Protease inhibitors (PIs), with the exception of indinavir, are more than 90% protein bound, mainly to alpha1-acid glycoprotein (AAG).
Boffito, Marta +6 more
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Antiretroviral therapy for children
Acta Paediatrica, 1994Advances in the development of antiviral drugs have been rapid and dramatic. Since the recognition of HIV‐1 as the cause of AIDS in 1984, and improved understanding of retroviral replication and pathogenesis, three antiviral drugs, Zidovudine, Didanosine, and Zalcitabine, have been developed to the point of routine use in humans.
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Initiation of antiretroviral therapy
Current Opinion in Internal Medicine, 2006Until there is a therapy or a vaccine that can eradicate HIV infection, it is important to continue debating the issues of when and how to use the many antiviral agents licensed as initial treatment since there remain many areas of uncertainty.Early initiation of treatment may be beneficial in terms of HIV progression but it has to be weighed against ...
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