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Zyn-Linker delivery of antirheumatic agents
Immunologic Research, 1994Despite our increasing ability to manage rheumatoid arthritis through systemic medication, refractory joints require local administration of more aggressive therapy in a substantial number of patients. These studies tested whether a new class of molecules designated Zyn-Linkers could deliver and retain therapeutics in a joint. Zyn-Linkers are synthetic
B M, Ohlsson-Wilhelm +7 more
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Pulmonary Disease Due to Antirheumatic Agents
Clinics in Chest Medicine, 1990Drug-induced lung disease presents several diagnostic and therapeutic problems to the clinician. This is especially true in the case of lung disease associated with antirheumatic agents in which pulmonary disease may be due to the underlying disorder.
R J, Zitnik, J A, Cooper
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Drug therapy reviews: Antirheumatic agents
American Journal of Health-System Pharmacy, 1979The pathophysiology, symptoms and drug treatment of rheumatic disease are reviewed. Antirheumatic drugs reviewed are salicylates (including aspirin, sodium salicylate, choline salicylate, choline magnesium salicylate, salsalate), phenylpropionic acid derivatives (fenoprofen, ibuprofen, naproxen), indole derivatives (sulindac, tolmetin and indomethacin),
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Articular Pharmacokinetics of Protein-Bound Antirheumatic Agents
Clinical Pharmacokinetics, 1993By what mechanism do nonsteroidal anti-inflammatory drugs (NSAIDs) move from plasma into synovial fluid and back, and how does binding to plasma albumin in vitro relate to articular transport in vivo? To evaluate these issues, concurrent plasma and synovial fluid data of 8 different NSAIDs from 10 single-dose trials were analysed by a simple ...
P A, Simkin, M P, Wu, D M, Foster
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