Results 181 to 190 of about 353,788 (280)

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source

Trends in paediatric antiseizure-medication use and costs in France, 2014-2023: a nationwide population-based analysis. [PDF]

Lancet Reg Health Eur
Nabbout R, Santilli A, Tyvaert L, Schweitzer C, Maillard L, Kuchenbuch M.   +5 more
europepmc   +1 more source

Long‐term prediction of epilepsy following traumatic brain injury among veterans using routine clinical data

Epilepsia, EarlyView.
Abstract Objective Despite elevated risk for epilepsy following traumatic brain injury (TBI), there are limited tools to assess epilepsy risk following TBI using routine clinical data. The objective of this study was to develop and validate a machine learning approach to predict the onset of posttraumatic epilepsy (PTE) over varying time horizons ...
Mustafa Ozmen, Shashank Vadlamani, James J. Gugger, Megan Amuan, Ramon Diaz‐Arrastia, Mary Jo Pugh, Eamonn Kennedy   +6 more
wiley   +1 more source

Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Dongjun Guo, Lirong Han, Nicholas R. Rensing, Laura A. Jansen, Michael Wong   +4 more
wiley   +1 more source

Long-term safety of early discontinuation of antiseizure medication after resolution of acute provoked neonatal seizures. [PDF]

Epilepsia
Glass HC, Numis AL, Soul JS, Wusthoff CJ, Lemmon ME, Chu CJ, Massey SL, Thomas C, Anwar T, Berl MM, Larson JG, Sturza J, Annis D, Rogers EE, Franck LS, McCulloch CE, Shellhaas RA.   +16 more
europepmc   +1 more source

Could calcitonin gene‐related peptide inhibitors prevent status epilepticus?

Epilepsia, EarlyView.
Abstract Calcitonin gene‐related peptide (CGRP) inhibitors modulate pain and neuroinflammation, a recognized contributor to epileptogenesis and status epilepticus (SE). We examined the association between CGRP inhibitor use and SE hospitalization in epilepsy patients with comorbid migraine.
Michael Nsaka, Noor Baban, Sepideh Allahdadian, Armin Scheffler, Diana Lindner, Dagny Holle, Alain Lekoubou   +6 more
wiley   +1 more source

Late Pregnancy Antiseizure Medication Exposure and Offspring Neurodevelopmental Risk: A Multi-Child Cohort Study. [PDF]

Ann Neurol
Sheehy O, Tchuente V, Eltonsy S, Hawken S, Kaul P, Walker M, Pugliese M, Dragan R, Savu A, Leal L, Morin L, Malhamé I, Pana R, Bérard A.   +13 more
europepmc   +1 more source

Revisiting the concept that interictal implies asymptomatic: Pulse wave amplitude drops uncover autonomic responses during generalized paroxysmal fast activities

Epilepsia, EarlyView.
Abstract Objective Interictal electroencephalographic (EEG) activities are generally considered asymptomatic. Pulse wave amplitude drop (PWAD) is a marker of autonomic nervous system (ANS) reactivity linked to cardiovascular risk. Generalized paroxysmal fast activity (GPFA) is a major EEG pattern in different epileptic conditions.
Julie Lévi‐Strauss, Valerio Frazzini, Claude Adam, Isabelle Gourfinkel‐An, Sophie Dupont, Vincent Navarro, Vi‐Huong Nguyen‐Michel   +6 more
wiley   +1 more source

On Time Saves Lives: Survey Insights and Position Statement from the American Epilepsy Society on Barriers to Antiseizure Medication Access. [PDF]

Epilepsy Curr
Bunch ME, Falco-Walter J, Alick-Lindstrom S, Al-Faraj AO, Fureman BE, Herbst J, Garrity LC, Klocke S, Lekoubou A, Marcuse LV, Orciuoli L.   +10 more
europepmc   +1 more source

Response to Ng et al. on “Stimulus‐induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges”

Epilepsia, EarlyView.
Philippe Gélisse, William O. Tatum, Arielle Crespel, Peter W. Kaplan   +3 more
wiley   +1 more source