Results 101 to 110 of about 443,792 (339)
Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake [PDF]
, 2016 Indexación: Web of Science.Poly(amidoamine) dendrimers are the most recognized class of dendrimer. Amino-terminated (PAMAM-NH2) and hydroxyl-terminated (PAMAM-OH) dendrimers of generation 4 are widely used, since they are commercially available.
Araya-Durán, Ingrid +10 more
core +1 more source
Antisense Oligonucleotide-Based Therapy for Neuromuscular Disease
Molecules, 2017 Neuromuscular disorders such as Duchenne Muscular Dystrophy and Spinal Muscular Atrophy are neurodegenerative genetic diseases characterized primarily by muscle weakness and wasting.
V. Sardone +4 more
semanticscholar +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Non-Coding RNA, 2020 This review aims to highlight the role of long non-coding RNAs in mediating human immunodeficiency virus (HIV-1) viral replication, latency, disease susceptibility and progression.
Roslyn M. Ray, Kevin V. Morris
doaj +1 more source
An Exonic Splicing Enhancer within a Bidirectional Coding Sequence Regulates Alternative Splicing of an Antisense mRNA [PDF]
, 2010 The discovery of increasing numbers of genes with overlapping sequences highlights the problem of expression in the context of constraining regulatory elements from more than one gene.
Hastings, Michelle Laura +4 more
core +1 more source
Plants lacking the main light-harvesting complex retain photosystem II macro-organization [PDF]
, 2003 Photosystem II (PSII) is a key component of photosynthesis, the process of converting sunlight into the chemical energy of life. In plant cells, it forms a unique oligomeric macrostructure in membranes of the chloroplasts.
A Haldrup +27 more
core +5 more sources
Kidney and Blood Pressure Research, 1996 Antisense oligonucleotides are being used as gene-therapeutic agents. This short overview focuses on the in vivo kinetics and on potential in vivo applications for research purposes as well as therapeutic applications. The most promising experimental results have been obtained with oligonucleotides targeted against genes involved in cell proliferation,
Oberbauer, R +3 more
openaire +2 more sources
Antisense RNA: the new favorite in genetic research
Journal of Zhejiang University SCIENCE B, 2018 Antisense RNA molecule represents a unique type of DNA transcript that comprises 19–23 nucleotides and is complementary to mRNA. Antisense RNAs play the crucial role in regulating gene expression at multiple levels, such as at replication, transcription,
Jian-zhong Xu +2 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]
, 2007 The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li +4 more
core +2 more sources