Results 71 to 80 of about 378,124 (311)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Climacteric fruit ripening: Ethylene-dependent and independent regulation of ripening pathways in melon fruit [PDF]

, 2008
Cantaloupe melons have a typical climacteric behaviour with ethylene playing a major role in the regulation of the ripening process and affecting the ripening rate.
A. Latché, Abeles, Alexander, Aubert, Ayub, Bauchot, Ben Amor, Bower, Clendennen, Dandekar, Defilippi, Defilippi, Deikman, El-Sharkawy, Ergun, Ezura, Flores, Flores, Flores, Giovannoni, Golding, Gray, Guis, Gussman, Hadfield, Hamilton, Harada, Hisawa, J.C. Pech, Jeffery, Koukounaras, Lafuente, Lelièvre, M. Bouzayen, Manríquez, Moore, Murray, Nishiyama, Nunez-Palenius, Obando, Oeller, Pesis, Porat, Périn, Rose, Selvarajah, Silva, Sitrit, Sunako, Tigchelaar, Vrebalov, Yahyaoui, Yang, Yang, Zegzouti, Zeroni, Zheng, Zheng   +57 more
core   +2 more sources

Antisense Sense in Osteoclasts [PDF]

The American Journal of Pathology, 2016
This commentary highlights the article by Li et al that proposes regulating Wilm's tumor-1 antisense RNA to control pathological bone resorption.
openaire   +3 more sources

Natural antisense transcripts [PDF]

Human Molecular Genetics, 2014
Recent years have seen the increasing understanding of the crucial role of RNA in the functioning of the eukaryotic genome. These discoveries, fueled by the achievements of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regulatory roles of natural antisense transcripts (NATs) arising from what was previously
Olga, Khorkova, Amanda J, Myers, Jane, Hsiao, Claes, Wahlestedt   +3 more
openaire   +2 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response

Scientific Reports
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is a highly abundant RNA binding protein alternatively spliced in two main isoforms named, hnRNP A1 and hnRNP A1B.
Jade-Emmanuelle Deshaies, Valérie Triassi, Andréanne Lacombe, Myriam Gagné, Karen Ling, Asmita Ghosh, Marjorie Labrecque, Frank Rigo, Paymaan Jafar-nejad, Martine Tétreault, Christine Vande Velde   +10 more
doaj   +1 more source

Interaction of α-Melanocortin and Its Pentapeptide Antisense LVKAT: Effects on Hepatoprotection in Male CBA Mice

Molecules, 2011
The genetic code defines nucleotide patterns that code for individual amino acids and their complementary, i.e., antisense, pairs. Peptides specified by the complementary mRNAs often bind to each other with a higher specificity and efficacy. Applications
Paško Konjevoda, Tin Weitner, Mario Gabričević, Petra Turčić, Karlo Houra, Nikola Štambuk   +5 more
doaj   +1 more source

Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex [PDF]

, 2012
The cognitive deficits of schizophrenia appear to be associated with altered cortical GABA neurotransmission in the subsets of inhibitory neurons that express either parvalbumin (PV) or somatostatin (SST).
Danko Georgiev, David A. Lewis, Guillermo González-Burgos, Mitsuru Kikuchi, Takanori Hashimoto, Takeo Yoshikawa, Yoshio Minabe   +6 more
core   +4 more sources

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source