Offline comprehensive liquid chromatography in combination with a Deoxyribonuclease I immobilized enzymatic reactor for selective screening of oligonucleotide mixtures [PDF]
, 2016 Alvarez Porebski, Piotr Wiktor +1 more
core +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Calcium ion (Ca2+) is an essential plant nutrient required for cell structure establishment, as well as a counter‐cation of an anion and an intracellular messenger. Calcium is absorbed from soil by roots and delivered to shoots through the xylem. The process must be finely balanced to avoid excessive accumulation.
Bojuan Liu +10 more
wiley +1 more source
Viral and non-viral cellular therapies for neurodegeneration. [PDF]
Front Med (Lausanne)Srivastav J, Sharma S.
europepmc +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Anthocyanins are plant pigments that contribute to fruit coloration and nutritional quality, yet the coordinated regulation of their accumulation in both peel and flesh remains elusive. Here, we present a haplotype‐resolved genome of Malus cv. ‘Royalty’, a model cultivar with consistently red peel and flesh. A zinc‐finger transcription factor,
Mengnan Zhao +8 more
wiley +1 more source
RFFL antisense oligonucleotides: A novel stabilization strategy to broaden the reach of CFTR modulator therapy. [PDF]
Mol Ther Nucleic AcidsPedemonte N.
europepmc +1 more source
Linking Superoxide Production and Scavenging in Plant Development
Plant, Cell &Environment, EarlyView.ABSTRACT Due to their strong oxidizing potential, rapid membrane permeability, and high reactivity, reactive oxygen species (ROS) play essential roles in plant development and stress responses. Superoxide (O2•‐) is a primary product of molecular oxygen reduction and a crucial source of hydrogen peroxide, representing a ROS species of substantial ...
Jan Řehák +3 more
wiley +1 more source
Artificial Intelligence-Driven Design of Antisense Oligonucleotides for Precision Medicine in Neuromuscular Disorders. [PDF]
Genes (Basel)Leckie J, Wu S, Standell T, Yokota T.
europepmc +1 more source
Intracellular cholesterol transporters and modulation of hepatic lipid metabolism: implications for diabetic dyslipidaemia and steatosis [PDF]
, 2014 Caridis, Anna-Maria +3 more
core +1 more source
Bodywide skipping of exons 45–55 in dystrophic mdx52 mice by systemic antisense delivery
Proceedings of the National Academy of Sciences of the United States of America, 2012 Y. Aoki +10 more
semanticscholar +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò +18 more
wiley +1 more source