Results 271 to 280 of about 263,255 (408)

The Highly Conserved Cys95 Residue of Fructose‐1,6‐Bisphosphatase 1 Mediates the pH‐Driven Structure and Activity of the Enzyme and Photosynthesis

Plant, Cell &Environment, EarlyView.
ABSTRACT In Arabidopsis, exposure to microbial volatile compounds promotes thiol reduction of the Cys95 residue of the photosynthetic enzyme fructose‐1,6‐bisphosphatase (cFBP1). Although highly conserved in plants, the Cys95 function still remains unknown. We characterised recombinant wild‐type (WT) cFBP1 and a variant (C95S) in which the Cys95 residue
Samuel Gámez‐Arcas, Edurne Baroja‐Fernández, Francisco José Muñoz, Antonio J. Serrato, Mónica Balsera, Ángela María Sánchez‐López, Abdellatif Bahaji, Jesús Leal‐López, Rafael Jorge León Morcillo, Javier Pozueta‐Romero   +9 more
wiley   +1 more source

Suppression of Gal.ALPHA.1-3Gal expression by antisense oligonucleotides specific for porcine .ALPHA.-1,3-galactosyltransferase mRNA treatment.

, 1998
Akiko Taguchi, Masanobu Arita, Yasunori Kushi, Shizuo Handa   +3 more
openalex   +2 more sources

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

Science Translational Medicine, 2017
Sarah J. Ross, A. Revenko, Lyndsey Hanson, Rebecca Ellston, A. Staniszewska, Nicky Whalley, Sanjay K. Pandey, M. Revill, C. Rooney, Linda K. Buckett, Stephanie K. Klein, K. Hudson, Brett P. Monia, M. Zinda, David C. Blakey, Paul D. Lyne, A. Macleod   +16 more
semanticscholar   +1 more source

Optimisation of Heated Electrospray Ionisation Parameters to Minimise In‐Source Generated Impurities in the Analysis of Oligonucleotide Therapeutics

Rapid Communications in Mass Spectrometry, Volume 39, Issue 13, 15 July 2025.
ABSTRACT Rationale Oligonucleotides have emerged as an important new class of therapeutic. Due to their structural complexity, this presents significant challenges for the development of analytical methods to characterise and determine their impurity profile.
Mollie A. Glenister, Ulrik Mistarz, Ken Cook, James L. Stephenson, Mark J. Dickman   +4 more
wiley   +1 more source

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song, Adrian H. Bustos, Lise Bastue, Justas Mikutavicius, Piotr Swiderski, Kelly J. Clemens, Nagy Habib, John Rossi, Kira Astakhova   +8 more
wiley   +2 more sources

Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells [PDF]

Mol Ther Nucleic Acids
Suzuki N.
europepmc   +2 more sources

Correcting tau isoform ratios with a long-acting antisense oligonucleotide alleviates 4R-tauopathy phenotypes. [PDF]

Mol Ther Nucleic Acids
Iwata-Endo K, Sahashi K, Kawai K, Fujioka Y, Okada Y, Watanabe E, Iwade N, Ishibashi M, Mohammad M, Aldoghachi AF, Tuerde D, Fujiwara T, Hirai S, Okado H, Katsuno M, Watanabe H, Kanamitsu K, Neya M, Ishigaki S, Sobue G.   +19 more
europepmc   +1 more source

Offline comprehensive liquid chromatography in combination with a Deoxyribonuclease I immobilized enzymatic reactor for selective screening of oligonucleotide mixtures [PDF]

, 2016
Alvarez Porebski, Piotr Wiktor, Lynen, Frederic   +1 more
core   +1 more source

Fluoxetine Treatment in Epilepsy of Infancy with Migrating Focal Seizures Due to KCNT1 Variants: An Open Label Study

Annals of Neurology, Volume 98, Issue 1, Page 48-61, July 2025.
Objective Gain‐of‐function (GoF) variants in KCNT1 encoding for potassium channels are associated with different epilepsy phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), other early infantile developmental and epileptic encephalopathies, and focal epilepsy.
Marina Trivisano, Ilaria Mosca, Licia Salimbene, Angela De Dominicis, Paolo Ambrosino, Deborah Puzo, Ilenio Servettini, Cinzia Correale, Chiara Falamesca, Cristina Filosomi, Bianca Goffredo, Maria Virginia Soldovieri, Maurizio Taglialatela, Nicola Specchio   +13 more
wiley   +1 more source

Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder. [PDF]

Nat Med
Ziegler A, Carroll J, Bain JM, Sands TT, Fee RJ, Uher D, Kanner CH, Montes J, Glass S, Douville J, Mignon L, Gleeson JG, Crooke ST, Chung WK.   +13 more
europepmc   +1 more source