Results 281 to 290 of about 263,255 (408)

Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background and Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common cause of liver disease and a leading contributor to liver‐related morbidity and mortality. Currently, no pharmacological approach has demonstrated consistent and long‐lasting benefits across all patients.
Mariateresa Pettinato, Valeria Furiosi, Rossana Carleo, Letizia Bavuso Volpe, Shuling Guo, Valeria Mannella, Giovanna Musco, Enrica Gilberti, Giuseppe De Palma, Giorgia Federico, Francesca Carlomagno, Alessandro Cherubini, Serena Pelusi, Anxhela Dano, Antonella Nai, Luca Valenti, Sandro Altamura, Alessia Pagani, Laura Silvestri   +18 more
wiley   +1 more source

Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile, Maria Teresa Cerasa, Antonia D'Aniello, Michele Saviano, Maria Moccia   +4 more
wiley   +1 more source

AZD8701, an Antisense Oligonucleotide Targeting FOXP3 mRNA, as Monotherapy and in Combination with Durvalumab: A Phase I Trial in Patients with Advanced Solid Tumors. [PDF]

Clin Cancer Res
Siu LL, Postel-Vinay S, Villanueva-Vázquez R, de Velasco G, Castanon Alvarez E, Kyriakopoulos CE, Johnson M, Ouali K, McMorn S, Angell HK, Ng F, Saran S, Bayat M, Collins T, Roy A, Lambert AW, Cho S, Miller N, Petruzzelli M, Stone J, Massard C.   +20 more
europepmc   +1 more source

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids [PDF]

, 2000
Claes Wahlestedt, Peter Salmi, Liam Good, Johanna Kela, Thomas Johnsson, Tomas Hökfelt, Christian Broberger, Frank Porreca, Josephine Lai, Kunkun Ren, Michael H. Ossipov, Alexei A. Koshkin, Nana Jakobsen, Jan Skouv, Henrik Oerum, Mogens Havsteen Jacobsen, Jesper Wengel   +16 more
openalex   +1 more source

MicroRNA‐100‐5p Exacerbates Myocardial Ischemia–Reperfusion Injury Through Downregulation of PRMT5

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
MiR‐100‐5p overexpression downregulates PRMT5, leading to increased PTEN activity and reduced AKT signaling. This molecular cascade promotes cardiomyocyte apoptosis, enhances fibrotic remodeling, and exacerbates cardiac dysfunction following myocardial ischemia–reperfusion injury.
Zhenya Wang, Tong‐You Wade Wei, Jo‐Mei Maureen Chen, Ke Zhang, Yiwei Zhang, Huiting Shi, Hsiang‐Chun Su, I‐Shan Hsieh, Chang‐Tze Ricky Yu, Guo‐Jun Zhao   +9 more
wiley   +1 more source

Mechanistic insights into ASO-RNA complexation: Advancing antisense oligonucleotide design strategies. [PDF]

Mol Ther Nucleic Acids
Hörberg J, Carlesso A, Reymer A.
europepmc   +1 more source

Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo. [PDF]

JHEP Rep
Noguchi M, Miyauchi A, Masaki Y, Sakaki M, Lei XF, Kobayashi-Tanabe M, Miyazaki A, Aoki T, Yoshida H, Seio K, Kim-Kaneyama JR.   +10 more
europepmc   +1 more source

Casimersen (AMONDYS 45™): An Antisense Oligonucleotide for Duchenne Muscular Dystrophy. [PDF]

Biomedicines
Assefa M, Gepfert A, Zaheer M, Hum JM, Skinner BW.   +4 more
europepmc   +1 more source

Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A [PDF]

, 2000
Fortunato Ciardiello, Rosa Caputo, G Pomatico, Michelino De Laurentiis, Sabino De Placido, Angelo Raffaele Bianco, Giampaolo Tortora   +6 more
openalex   +1 more source

Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects. [PDF]

Nat Commun
Leclair NK, Brugiolo M, Park S, Devoucoux M, Urbanski L, Angarola BL, Yurieva M, Anczuków O.   +7 more
europepmc   +1 more source