Results 281 to 290 of about 266,614 (380)

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells [PDF]

Mol Ther Nucleic Acids
Suzuki N.
europepmc   +2 more sources

Antisense oligonucleotide allele-specific targeting of EFEMP1 in a patient-derived model of Doyne honeycomb retinal dystrophy

Rezek FO, Sanchez-Pintado B, Eden ER, Aychoua N, Webster AR, Carr AF, Michaelides M, Cheetham ME, van der Spuy J.   +8 more
europepmc   +1 more source

Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder. [PDF]

Nat Med
Ziegler A, Carroll J, Bain JM, Sands TT, Fee RJ, Uher D, Kanner CH, Montes J, Glass S, Douville J, Mignon L, Gleeson JG, Crooke ST, Chung WK.   +13 more
europepmc   +1 more source

Sensitivity of splice sites to antisense oligonucleotides in vivo

, 1999
HALINA SIERAKOWSKA, MARIA J. SAMBADE, DANIEL SCHÜMPERLI, RYSZARD KOLE   +3 more
openalex   +2 more sources

IbPIF1 confers stem nematode resistance by regulating secondary metabolites in sweet potato

Plant Biotechnology Journal, EarlyView.
Summary The stem nematode (Ditylenchus destructor Thorne) is a pervasive and destructive plant‐parasitic nematode worldwide, inflicting severe agricultural and economic losses in a wide range of crops. Despite its global impact, the molecular mechanisms underlying plant resistance to this pathogen remain poorly understood. Our previous studies in sweet
Nan Nie, Yinghui Yang, Jinxi Huo, Feibing Wang, Ruitao Liu, Sifan Sun, Yuanfeng Hu, Yanqi Chen, Wenxin Wu, Qingchang Liu, Shaozhen He, Huan Zhang, Ning Zhao, Shaopei Gao, Hong Zhai   +14 more
wiley   +1 more source

In vivo scintillation imaging of 131I-labelled c-myc antisense oligonucleotides after arterial transfection

, 1996
Rémi Martel, Angelica Fleser, Neil Hartman, Jean‐Paul Soucy, Martin Bouchard, Pierre Voisine, Guy Leclerc   +6 more
openalex   +1 more source

A natural variation in the promoter of TaGDSL‐7D contributes to grain weight and yield in wheat

Plant Biotechnology Journal, EarlyView.
Summary Grain weight (GW) is a critical agronomic trait that greatly impacts wheat yield, yet the underlying genetic factors remain largely unknown. Here, we identify and characterize a candidate gene TaGDSL‐7D controlling GW in wheat through map‐based cloning, which encodes an ER‐located GDSL‐family protein.
Fei He, Dejie Du, Zhaoyan Chen, Liang Ma, Yunjie Liu, Zhaoju Li, Long Song, Zihao Jiang, Yujie Fan, Qixin Sun, Zhongfu Ni   +10 more
wiley   +1 more source

AZD8701, an Antisense Oligonucleotide Targeting FOXP3 mRNA, as Monotherapy and in Combination with Durvalumab: A Phase I Trial in Patients with Advanced Solid Tumors. [PDF]

Clin Cancer Res
Siu LL, Postel-Vinay S, Villanueva-Vázquez R, de Velasco G, Castanon Alvarez E, Kyriakopoulos CE, Johnson M, Ouali K, McMorn S, Angell HK, Ng F, Saran S, Bayat M, Collins T, Roy A, Lambert AW, Cho S, Miller N, Petruzzelli M, Stone J, Massard C.   +20 more
europepmc   +1 more source