Results 161 to 170 of about 144,032 (247)

Sydnone-modified nucleosides as versatile tools for bioorthogonal post-synthetic functionalization of antisense oligonucleotides. [PDF]

RSC Chem Biol
Bristiel A, Khuu A, Poulet M, Taran F, Urban D, Guignard R, Guianvarc'h D.   +6 more
europepmc   +1 more source

Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source

Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides. [PDF]

Nucleic Acids Res
Barber HM, Parasrampuria MA, Jurado-Arjona J, Gamir-Morralla A, Berninger B, González C, Gagnon KT, Damha MJ, Garavís M.   +8 more
europepmc   +1 more source

Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model. [PDF]

Brain
Meng J, Ma S, Lone MA, Lam HW, Zhang Q, Cheng S, Mackie S, Graham E, Kedzior H, Demetriou C, Ziak N, Andreoli L, Beggs S, Koch S, Clark AJ, Bennett DL, Hornemann T, Muntoni F, Reilly MM, Zhou H.   +19 more
europepmc   +1 more source

Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides. [PDF]

Nat Commun
Hjelmgren L, Zhou Q, Schmidli S, Gloudemans M, Czapik T, Roudi S, Honcharenko M, Hagey DW, El Andaloussi S, Farnebo M.   +9 more
europepmc   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Antisense Oligonucleotides: Technological Advances, Clinical Progress, and Expanding Therapeutic Frontiers. [PDF]

Pharmaceutics
Xu L, Zhang H, Jiang B, Jiang Y, Lu H.
europepmc   +1 more source

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia. [PDF]

Front Oncol
Lin HY, Khou S, Lind E, de Oliveira Rebola KG, Dean A, Zhang H, Tolentino A, Maazi H, Revenko A, Agarwal A.   +9 more
europepmc   +1 more source

Chemical and Biological Determinants of PEG‐Lipid Shedding From Therapeutic Nanoparticles

Small, EarlyView.
PEG‐lipids play a central role in governing lipid nanoparticle stability, targeting, and function. However, PEG‐lipids can “shed” from the nanoparticle surface in biological environments, with the extent and kinetics of shedding influenced by chemical and biological factors.
Ethan P. Cisneros, Aadya S. Wijesekera, Lisa R. Volpatti   +2 more
wiley   +1 more source