Results 181 to 190 of about 125,197 (343)

Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity. [PDF]

RSC Chem Biol
Katsuyama M, Matsubayashi T, Ying Y, Mon SSL, Kuroda T, Yoshida-Tanaka K, Hara RI, Yamada T, Ui-Tei K, Yoshioka K.   +9 more
europepmc   +1 more source

RNA interference is ineffective as a routine method for gene silencing in chick embryos as monitored by fgf8 silencing.

, 2013
The in vivo accessibility of the chick embryo makes it a favoured model system for experimental developmental biology. Although the range of available techniques now extends to miss-expression of genes through in ovo electroporation, it remains difficult
Bueno i Torrens, David, 1965-, Hernández Hernández, Victor   +1 more
core  

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Characterisation of Antisense Oligonucleotides by Ion-Pair Reversed-Phase UHPLC-HRMS: Method development using Design of Experiments. [PDF]

J Mass Spectrom
Triolo A, Tavani F, Barnini P, Furlanetto S, Orlandini S.   +4 more
europepmc   +1 more source

Defining Synphenotype Groups in Xenopus tropicalis by Use of Antisense Morpholino Oligonucleotides

, 2006
Amer A. Rana, Clara Collart, Michael J. Gilchrist, James C. Smith   +3 more
openalex   +2 more sources

Data from Inhibition of <i>STAT3</i> with the Generation 2.5 Antisense Oligonucleotide, AZD9150, Decreases Neuroblastoma Tumorigenicity and Increases Chemosensitivity

, 2023
Seiichi Odate, Veronica Veschi, Shuang Yan, Norris Lam, Richard Woessner, Carol J. Thiele   +5 more
openalex   +1 more source

Clinical‐Grade Human Induced Pluripotent Stem Cell‐Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid‐Lesioned Rat Model of Huntington's Disease

Cell Proliferation, EarlyView.
Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon, Il‐Shin Lee, Sanghun Lee, Hyo Chang Park, Beomsoo Kim, Hyun Sook Kim, Jihwan Song   +6 more
wiley   +1 more source

A xenotransplantation model for reactivation of paternal UBE3A using human-specific antisense oligonucleotides. [PDF]

Sci Rep
Smeenk H, Lendemeijer B, Buurma MG, Forgione MA, Slump DE, Monshouwer RA, Wallaard I, Mientjes EJ, Hoogendijk WJG, Elgersma Y, de Vrij FMS, Kushner SA.   +11 more
europepmc   +1 more source

Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol [PDF]

, 1999
Maria Kavallaris, Catherine A. Burkhart, Susan Band Horwitz   +2 more
openalex   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source