Results 191 to 200 of about 125,197 (343)

Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol [PDF]

, 2015
Tomoko Nishina, Junna Numata, Kazutaka Nishina, Kie Yoshida‐Tanaka, Keiko Nitta, Wenying Piao, Rintaro Iwata, Shingo Ito, Hiroya Kuwahara, Takeshi Wada, Hidehiro Mizusawa, Takanori Yokota   +11 more
openalex   +1 more source

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Chemically inducible antisense oligonucleotides for cell-specific gene silencing. [PDF]

RSC Chem Biol
Xun Z, Hai Y, Tang LJ, Jiang JH, Wu Z.
europepmc   +1 more source

Targeting of the Transcription Factor STAT4 by Antisense Phosphorothioate Oligonucleotides Suppresses Collagen-Induced Arthritis [PDF]

, 2007
Kai Hildner, Peter Schirmacher, Imke Atreya, Maria Dittmayer, Brigitte Bartsch, Peter R. Galle, Stefan Wirtz, Markus F. Neurath   +7 more
openalex   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Antisense oligonucleotides to KIF1A polymorphisms expand targets and rescue patient-derived neurons in vitro. [PDF]

Nat Commun
Zuccaro MV, Young RE, Hu J, Lanzano P, Semenova E, Lin X, Skowronski A, Shen Y, Kim TH, Miller DE, Germain N, Sarmiere P, LeDuc CA, Chung WK.   +13 more
europepmc   +1 more source

A novel dual lock method for down-regulation of genes, in which a target mRNA is captured at 2 independent positions by linked locked nucleic acid antisense oligonucleotides [PDF]

, 2016
Ryohei Takata, Gouki Makado, Ayaka Kitamura, Hajime Watanabe, Tadashi Wada   +4 more
openalex   +1 more source

Post‐transcriptional regulatory networks: The dynamic interplay of RNA‐binding proteins

The FEBS Journal, EarlyView.
Post‐transcriptional gene expression regulation is controlled by RNA‐binding proteins (RBPs), which influence many processes including splicing, localization, translation, and decay. Rather than acting alone, RBPs bind RNAs combinatorially, forming complex, context‐dependent regulatory networks.
Lena A. Street, Marko Jovanovic, Eugenio F. Fornasiero   +2 more
wiley   +1 more source

Artificial Intelligence-Driven Design of Antisense Oligonucleotides for Precision Medicine in Neuromuscular Disorders. [PDF]

Genes (Basel)
Leckie J, Wu S, Standell T, Yokota T.
europepmc   +1 more source