Results 211 to 220 of about 144,032 (247)

RNA Therapeutics: Focus on Antisense Oligonucleotides in the Nervous System. [PDF]

Biomol Ther (Seoul)
Ertural B, Çiçek BN, Kurnaz IA.
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Targeting rare splicing defects: Antisense oligonucleotides offer a therapeutic strategy in FRDA. [PDF]

Mol Ther Nucleic Acids
Kerkhof LMC, Buijsen RAM.
europepmc   +1 more source

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Peptides and oligonucleotides are increasingly used as therapeutic agents, making the identification and structural elucidation of their metabolites a critical step in drug development. Liquid chromatography–mass spectrometry (LC‐MS/MS) is the primary analytical technique for this purpose; however, extensive backbone fragmentation ...
Paula Cifuentes, Albert Garriga, Fabien Fontaine, Ismael Zamora   +3 more
wiley   +1 more source

Freezing shock monocytes deliver antisense oligonucleotides via liposomes for the treatment of idiopathic pulmonary fibrosis. [PDF]

Asian J Pharm Sci
Li H, Wu X, Li J, Han L, Liu H, Jiang Q, Liu B, Xia Q, Li Z, Li X, Gu S, Xu A, Zhou H, Gu X, Xu Z, Ai X, Yang C.   +16 more
europepmc   +1 more source

Dravet Syndrome: A Primer for Behavior Analysts

Behavioral Interventions, Volume 41, Issue 4, November 2026.
ABSTRACT Dravet syndrome (DS) is a rare and severe developmental and epileptic encephalopathy that is characterized by prolonged seizures beginning in the first year of life, followed by debilitating and complex features, including sleep disturbances, feeding problems, social‐emotional difficulties, speech deficits, and cognitive and motor impairments.
Isabel B. Hayes, Kasey E. Bedard, A. Delyla Ulm, Veronica Robbins‐Hood   +3 more
wiley   +1 more source

<i>DUX4</i> reduction and muscle function improvement by subcutaneous delivery of gapmer antisense oligonucleotides. [PDF]

Mol Ther Nucleic Acids
Zhang A, Lim KRQ, Chen Z, Yokota T, Chen YW.   +4 more
europepmc   +1 more source

Design, Synthesis and Biophysical Characterisation of CPP‐PNA Conjugates for Targeting Oncogenic microRNA‐221

Journal of Peptide Science, Volume 32, Issue 11, November 2026.
Cell‐penetrating peptide‐peptide nucleic acid (CPP‐PNA) conjugates that target the oncogenic microRNA‐221‐5p were synthesised using Cu(I)‐catalysed azide‐alkyne cycloaddition (CuAAC) and disulfide‐mediated conjugation strategies. These constructs form highly stable, sequence‐selective PNA/RNA heteroduplexes and demonstrate preliminary antiproliferative
Martina Rotondo, Françoise Illien, Fabienne Burlina, Barbara Biondi   +3 more
wiley   +1 more source