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Innovations in the Use of Antisense Oligonucleotides

Annals of the New York Academy of Sciences, 1990
The use of antisense oligonucleotides for controlling genetic expression has recently received widespread attention, especially as a new class of potential chemotherapeutic agents. This coupled with the urgency of developing new effective therapies for acquired immunodeficiency syndrome (AIDS) has led to various antisense studies dealing with human ...
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Antisense oligonucleotide strategies in physiology

Molecular and Cellular Endocrinology, 1994
Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA coding sequence.
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Antisense oligonucleotides as therapeutics for hyperlipidaemias

Expert Opinion on Biological Therapy, 2005
Hyperlipidaemia, due to elevations of low-density lipoprotein cholesterol (LDL-C) or triglycerides (TGs), is recognised as a significant risk factor contributing to the development of coronary heart disease (CHD), the leading cause of morbidity and mortality in the Western world.
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Antisense Oligonucleotides as Antiviral Agentsa