Results 221 to 230 of about 72,117 (255)
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Therapeutic implications of antisense oligonucleotides
International Journal of Clinical & Laboratory Research, 1992Antisense oligonucleotides and their derivatives have been shown to be specific inhibitors of gene expression. They are considered a very promising new generation of drugs, potentially useful in most human diseases, including cancers and viral infections.
D. Lattuada +3 more
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History of Antisense Oligonucleotides
2003Biological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery of the double helical structure of DNA in 1953 (1) caused such an event, with flooding of new information into the area now known as molecular biology.
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Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1997
Among the approaches which have been followed to convert a natural antisense phosphodiester oligonucleotide into a potential therapeutic agent, conjugation chemistry seems to be one of the most attractive. Indeed, natural phosphodiester oligonucleotide have the ideal properties (sequence specific hybridization, RNaseH activation, low or no toxicity ...
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Among the approaches which have been followed to convert a natural antisense phosphodiester oligonucleotide into a potential therapeutic agent, conjugation chemistry seems to be one of the most attractive. Indeed, natural phosphodiester oligonucleotide have the ideal properties (sequence specific hybridization, RNaseH activation, low or no toxicity ...
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Structural modifications of antisense oligonucleotides
Il Farmaco, 2003Antisense oligonucleotides are efficient tools for the inhibition of gene expression in a sequence specific way. Natural oligonucleotides are decomposed rapidly in biological systems, which strongly restrict their application. In contrast, artificial oligonucleotides are designed to be more stable against degradation than the target mRNA, which results
Urban, Ernst, Noe, Christian
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ANTISENSE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS
Pharmacological Research, 1997The potential for modulating gene expression by the use of antisense oligonucleotides has become increasingly interesting in recent years. Antisense oligonucleotides are complementary nucleic acid fragments that hybridize to target sequences within RNA to form a DNA-RNA duplex, resulting in the block of translation of messenger RNA into the protein ...
ALAMA A +3 more
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Antisense Oligonucleotide Therapy in Urology
Journal of Urology, 2002Antisense oligonucleotides are short modified DNA or RNA molecules designed to bind selectively messenger RNA and inhibit synthesis of the encoded protein. In the last 20 years antisense technology has emerged as an exciting and promising strategy, especially for treating cancer.
I, Kausch, A, Böhle
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Progress in Antisense Oligonucleotide Therapeutics
Annual Review of Pharmacology and Toxicology, 1996The past several years have seen substantial progress in the development of antisense oligonucleotides as pharmacological tools and as therapeutic agents. With properly designed and executed experiments, it has been possible to demonstrate selective inhibition of gene expression, owing to an antisense mechanisms of action both in cell culture-based ...
S T, Crooke, C F, Bennett
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Antisense and/or Immunostimulatory Oligonucleotide Therapeutics
Current Cancer Drug Targets, 2001Antisense technology, which is based on a simple and rational principle of Watson-Crick complementary base pairing of a short oligonucleotide with the targeted mRNA to downregulate the disease-causing gene product, has progressed tremendously in the last two decades.
S, Agrawal, E R, Kandimalla
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Seminars in cancer biology, 1992
Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene ...
CALABRETTA, Bruno, Skorski T, Zon G.
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Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene ...
CALABRETTA, Bruno, Skorski T, Zon G.
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Antisense oligonucleotides as antiviral agents
Trends in Biotechnology, 1992Antisense oligonucleotides are an attractive potential alternative to conventional drugs as antiviral agents. A major advantage is the relatively simple rational design of oligonucleotides which should bind only to specific nucleic acid sequences, compared with conventional drugs which are frequently targeted against sites of unknown structure in ...
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