Results 251 to 260 of about 125,197 (343)

STAT Signaling and Its Anti‐Apoptotic Effects in Dehydrated Xenopus laevis

Biology of the Cell, Volume 118, Issue 5, May 2026.
Dehydrated Xenopus laevis showed increased STAT3 and downstream anti‐apoptotic protein activation in the liver, whereas skeletal muscle saw increased STAT5 and downstream anti‐apoptotic protein activation, and decreased STAT1 activation. Collectively, these adaptations lead to decreased apoptosis, likely serving to protect against aestivation‐induced ...
Yulia Biggar, Akshay A. Kamath, Sarah A. Breedon, Kenneth B. Storey   +3 more
wiley   +1 more source

Expansion of Splice-Switching Therapy with Antisense Oligonucleotides. [PDF]

Int J Mol Sci
Takeshima Y.
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Tofersen and other antisense oligonucleotides in ALS. [PDF]

Ther Adv Neurol Disord
Ludolph A, Wiesenfarth M.
europepmc   +1 more source

Rebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration

Cell Proliferation, Volume 59, Issue 5, May 2026.
Summary of the functions of the NTRK2 receptor during lung injury and regeneration. Our recent work using both human organoid and mouse disease models highlights the non‐conventional role of NTRK2 isoforms in regulating pulmonary vasculature and alveolar regeneration during bronchopulmonary dysplasia.
Gan Zhou, Cheng Tan, Yifei Miao
wiley   +1 more source

SNA-modified antisense oligonucleotides: A new pathway for renal targeting? [PDF]

Mol Ther Nucleic Acids
Dumoulin B, Yamada K, Susztak K.
europepmc   +1 more source

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

Single Antisense Oligonucleotides Correct Diverse Splicing Mutations in Hotspot Exons. [PDF]

Proc Natl Acad Sci U S A
Duan C, Rong S, Buerer L, Neil CR, Zhong Y, Lyu Z, Savatt JM, Strande NT, Fairbrother WG.   +8 more
europepmc   +1 more source

SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
wiley   +1 more source