Results 61 to 70 of about 861,233 (259)

Biological Functions of Natural Antisense Transcripts

Acta Biochimica Polonica, 2017
Natural antisense transcripts (NATs) are RNA molecules that originate from opposite DNA strands of the same genomic locus (cis-NAT) or unlinked genomic loci (trans-NAT). NATs may play various regulatory functions at the transcriptional level via transcriptional interference.
Wojciech, Rosikiewicz, Izabela, Makałowska   +1 more
openaire   +3 more sources

Prediction of trans-antisense transcripts in Arabidopsis thaliana [PDF]

Genome Biology, 2006
Abstract Background Natural antisense transcripts (NATs) are coding or non-coding RNAs with sequence complementarity to other transcripts (sense transcripts). These RNAs could potentially regulate the expression of their sense partner(s) at either the transcriptional or ...
Huan Wang, Nam-Hai Chua, Xiu-Jie Wang
openaire   +3 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Spt5 orchestrates cryptic transcript suppression and transcriptional directionality

Communications Biology
Spt5 is a well-conserved factor that manipulates multiple stages of transcription from promoter-proximal pausing (PPP) to termination. Recent studies have revealed an unexpected increase of antisense transcripts near promoters in cells expressing mutant ...
Haejin An, Hyeokjun Yang, Daeyoup Lee
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

In-depth transcriptome analysis reveals novel TARs and prevalent antisense transcription in human cell lines. [PDF]

PLoS ONE, 2010
Several recent studies have indicated that transcription is pervasive in regions outside of protein coding genes and that short antisense transcripts can originate from the promoter and terminator regions of genes.
Daniel Klevebring, Magnus Bjursell, Olof Emanuelsson, Joakim Lundeberg   +3 more
doaj   +1 more source

Natural antisense transcription from a comparative perspective.

Genomics, 2016
Natural antisense transcripts (NATs) can interfere with the expression of complementary sense transcripts with exquisite specificity. We have previously cloned NATs of Slc34a loci (encoding Na-phosphate transporters) from fish and mouse. Here we report the cloning of a human SLC34A1-related NAT that represents an alternatively spliced PFN3 transcript ...
Piatek MJ, Henderson V, Zynad HS, Werner A.   +3 more
europepmc   +4 more sources

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Mutually exclusive sense–antisense transcription at FLC facilitates environmentally induced gene repression

Nature Communications, 2016
Antisense transcription from genic regions is a common phenomenon. Here Rosa et al. use single molecule FISH to show that during vernalization in Arabidopsis, cold-induced antisense transcription of COOLAIR is mutually exclusive to sense-strand ...
Stefanie Rosa, Susan Duncan, Caroline Dean   +2 more
doaj   +1 more source

Non-coding antisense transcription detected by conventional and single-stranded cDNA microarray

BMC Genomics, 2007
Background Recent studies revealed that many mammalian protein-coding genes also transcribe their complementary strands. This phenomenon raises questions regarding the validity of data obtained from double-stranded cDNA microarrays since hybridization to
Borg Åke, Medstrand Patrik, Kvist Anders, Staaf Johan, Vallon-Christersson Johan, Rovira Carlos   +5 more
doaj   +1 more source