Results 41 to 50 of about 861,233 (259)
Technology in Cancer Research & Treatment, 2020 Background: PTPRG antisense RNA 1 has been well-documented to exert an oncogenic role in diverse neoplasms. However, the precise role of PTPRG antisense RNA 1 in regulating radiosensitivity of nonsmall cell lung cancer cells remains largely elusive ...
Qiang Ma MB +7 more
doaj +1 more source
Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. [PDF]
PLoS Genetics, 2012 Histone H3 di- and trimethylation on lysine 4 are major chromatin marks that correlate with active transcription. The influence of these modifications on transcription itself is, however, poorly understood.
Thanasis Margaritis +10 more
doaj +1 more source
Transcription elongation is finely tuned by dozens of regulatory factors
eLife, 2022 Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments.
Mary Couvillion +7 more
doaj +1 more source
Sense and antisense OsDof12 transcripts in rice [PDF]
BMC Molecular Biology, 2008 Antisense transcription is a widespread phenomenon in plants and mammals. Our previous data on rice gene expression analysis by microarray indicated that the sense and antisense transcripts at the OsDof12 locus were co-expressed in leaves. In current study, we analyzed the expression patterns in detail and looked for the possible mechanism related to ...
Li, Dejun +4 more
openaire +2 more sources
iRAPs curb antisense transcription in E. coli. [PDF]
Nucleic Acids Res, 2019 RNA polymerase-binding RNA aptamers (RAPs) are natural RNA elements that control transcription in cis by directly contacting RNA polymerase. Many RAPs inhibit transcription by inducing Rho-dependent termination in Escherichia coli.
Magán A +7 more
europepmc +2 more sources
NATsDB: Natural Antisense Transcripts DataBase [PDF]
Nucleic Acids Research, 2007 Natural antisense transcripts (NATs) are reverse complementary at least in part to the sequences of other endogenous sense transcripts. Most NATs are transcribed from opposite strands of their sense partners. They regulate sense genes at multiple levels and are implicated in various diseases.
Yong Zhang +5 more
openaire +2 more sources
CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape
eLife, 2017 CRISPRi, an adapted CRISPR-Cas9 system, is proposed to act as a strand-specific roadblock to repress transcription in eukaryotic cells using guide RNAs (sgRNAs) to target catalytically inactive Cas9 (dCas9) and offers an alternative to genetic ...
Françoise S Howe +6 more
doaj +1 more source
Antisense Transcription in the Human Cytomegalovirus Transcriptome [PDF]
Journal of Virology, 2007 ABSTRACT Human cytomegalovirus (HCMV) infections are prevalent in human populations and can cause serious diseases, especially in those with compromised or immature immune systems. The HCMV genome of 230 kb is among the largest of the herpesvirus genomes.
Guojuan, Zhang +7 more
openaire +2 more sources
Natural antisense transcripts as therapeutic targets [PDF]
Drug Discovery Today: Therapeutic Strategies, 2013 At the turn of the 21st century, the central dogma of molecular biology was challenged by the unexpected discovery that only 1.2% of all genes transcribed from the human genome actually encode proteins. In fact, large-scale sequencing of the human and mouse genomes revealed that the other 99% is comprised of thousands of non-protein coding transcripts ...
Paul, Halley +2 more
openaire +2 more sources
Antisense Transcription in the Mammalian Transcriptome
Antisense transcription (transcription from the opposite strand to a proteincoding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at ...
Caminci P +28 more
core +5 more sources