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The functions of natural antisense transcripts [PDF]

Essays in Biochemistry, 2013
NATs (natural antisense transcripts) are widespread in eukaryotic genomes. Experimental evidence indicates that sense and antisense transcripts interact, suggesting a role for NATs in the regulation of gene expression. On the other hand, the transcription of a gene locus in both orientations and RNA hybrid formation can also lead to transcriptional ...
Megan, Wight, Andreas, Werner
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Natural antisense transcripts as drug targets

Frontiers in Molecular Biosciences, 2022
The recent discovery of vast non-coding RNA-based regulatory networks that can be easily modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities. Long non-coding RNA, and natural antisense transcripts (NATs) in particular, play a significant role in networks that involve a wide variety of disease-relevant biological ...
Olga Khorkova, Jack Stahl, Aswathy Joji, Aswathy Joji, Claude-Henry Volmar, Zane Zeier, Claes Wahlestedt, Claes Wahlestedt   +7 more
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Overlapping antisense transcription in the human genome [PDF]

Comparative and Functional Genomics, 2002
AbstractAccumulating evidence indicates an important role for non‐coding RNA molecules in eukaryotic cell regulation. A small number of coding and non‐coding overlapping antisense transcripts (OATs) in eukaryotes have been reported, some of which regulate expression of the corresponding sense transcript.
Fahey, M. E., Moore, T. F., Higgins, D. G.   +2 more
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Antisense-strand transcription correlates with sense-strand reactivation.

, 2023
(A) DESeq2-normalised counts for sense and antisense strand transcripts normalised to their maximum values. (B) DESeq2-normalised counts of reads aligned to the proviral sense or antisense-strand exons. Linear model fit with 95% confidence interval shown.
David S. Rueda (7879094), Aris E. N. Aristodemou (16715714), Charles R. M. Bangham (7879097), Graham P. Taylor (6678695)   +3 more
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Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues [PDF]

, 2009
Background: More than 20% of human transcripts have naturally occurring antisense products (or natural antisense transcripts – NATs), some of which may play a key role in a range of human diseases.
Oliver, G.R., Kendrick, H., Jat, P., Oliver, Gavin, Neville, A.M., Gavin R Oliver, Howard Kendrick, Tanney, Austin, Tanney, A., Grigoriadis, A., Grigoriadis, Anita, Smalley, M.J., Austin Tanney, Anita Grigoriadis, Kendrick, Howard, Jat, Parmjit, Matt J Smalley, A Munro Neville, Neville, A. Munro, Parmjit Jat, Smalley, Matthew John   +20 more
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Natural Antisense Transcripts [PDF]

RNA Biology, 2005
The sequencing of whole genomes and the subsequent annotation of cDNAs revealed that about 20% of human and mouse genes overlap resulting in potential pairs of sense and antisense transcripts. An increasing number of experimentally identified antisense transcripts concur with this predication.
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Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUX4 production. [PDF]

PLoS ONE, 2012
Facioscapulohumeral Disease (FSHD) is a dominantly inherited progressive myopathy associated with aberrant production of the transcription factor, Double Homeobox Protein 4 (DUX4).
Gregory J Block, Lisa M Petek, Divya Narayanan, Amanda M Amell, James M Moore, Natalia A Rabaia, Ashlee Tyler, Silvere M van der Maarel, Rabi Tawil, Galina N Filippova, Daniel G Miller   +10 more
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Seeking sense of antisense switch transcripts [PDF]

Transcription, 2011
In B lymphocytes, class switch recombination (CSR) machinery targets highly repetitive sequences, called switch (S) sequences, in the constant domain of the immunoglobulin heavy chain (IgH) locus. Cotranscriptional generation of R loops at S sequences provides the substrate for the mutagenic enzyme AID (Activation-Induced cytidine Deaminase), which ...
Dania, Haddad, Nadine, Puget, Nathalie, Laviolette-Malirat, Caroline, Conte, Ahmed Amine, Khamlichi   +4 more
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The Signal and the Noise: Characteristics of Antisense RNA in Complex Microbial Communities

mSystems, 2020
High-throughput sequencing has allowed unprecedented insight into the composition and function of complex microbial communities. With metatranscriptomics, it is possible to interrogate the transcriptomes of multiple organisms simultaneously to get an ...
Thomas Yssing Michaelsen, Jakob Brandt, Caitlin Margaret Singleton, Rasmus Hansen Kirkegaard, Johanna Wiesinger, Nicola Segata, Mads Albertsen   +6 more
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Regulatory roles of natural antisense transcripts [PDF]

Nature Reviews Molecular Cell Biology, 2009
Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features.
Mohammad Ali, Faghihi, Claes, Wahlestedt
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