Results 11 to 20 of about 861,233 (259)

Antisense transcription in Pseudomonas aeruginosa [PDF]

Microbiology (United Kingdom), 2018
A large number of antisense transcripts have been detected in diverse microbial genomes and considerable effort has been devoted to elucidating the functional role of antisense transcription.
Denitsa Eckweiler, Susanne Häusler
exaly   +7 more sources

Antisense transcription as a tool to tune gene expression [PDF]

Molecular Systems Biology, 2016
A surprise that has emerged from transcriptomics is the prevalence of genomic antisense transcription, which occurs counter to gene orientation. While frequent, the roles of antisense transcription in regulation are poorly understood.
Jennifer AN Brophy, Christopher A Voigt
doaj   +7 more sources

Nucleosome positioning shapes cryptic antisense transcription. [PDF]

PLoS Genetics
Maintaining transcriptional fidelity is essential for precise gene regulation and genome stability. Despite this, cryptic antisense transcription, occurring opposite to canonical coding sequences, is a pervasive feature across all domains of life.
Jian Yi Kok, Zachary H Harvey, Elin Axelsson, Frédéric Berger   +3 more
doaj   +4 more sources

Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription

Cell Reports, 2020
Summary: Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized ...
Jatinder Kaur Gill, Andrea Maffioletti, Varinia García-Molinero, Françoise Stutz, Julien Soudet   +4 more
doaj   +4 more sources

Antisense transcription in the mammalian transcriptome

Science, 2005
Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at ...
Hallinan, J. S., Nakamura, M., Mattick, J. S., Wells, C. A., Kasukawa, T., Ravasi, T., Waki, K., Frith, M., Nakanishi, M., Katayama, S., Tomaru, Y., Nishida, H., Hume, D. A., RIKEN GER Group,, Pang, K. C.   +14 more
core   +7 more sources

R-Loops as Promoters of Antisense Transcription [PDF]

Molecular Cell, 2019
The study by Tan-Wong et al. (2019) in this issue of Molecular Cell reveals a capacity of R-loops to promote antisense transcription expanding our view of the features that a DNA region may have to act as a promoter.The study by Tan-Wong et al. (2019) in
Rondón, Ana G., Aguilera, Andrés, Rondón, Ana G   +2 more
core   +5 more sources

Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters.

PLoS Genetics, 2016
Antisense transcription is a prevalent feature at mammalian promoters. Previous studies have primarily focused on antisense transcription initiating upstream of genes.
Christopher A Lavender, Kimberly R Cannady, Jackson A Hoffman, Kevin W Trotter, Daniel A Gilchrist, Brian D Bennett, Adam B Burkholder, Craig J Burd, David C Fargo, Trevor K Archer   +9 more
doaj   +2 more sources

Reduction of antisense transcription affects bovine leukemia virus replication and oncogenesis. [PDF]

PLoS Pathogens
In sheep infected with bovine leukemia virus (BLV), transcription of structural, enzymatic, and accessory genes is silenced. However, the BLV provirus transcribes a series of non-coding RNAs that remain undetected by the host immune response ...
Thomas Joris, Thomas Jouant, Jean-Rock Jacques, Lorian Gouverneur, Xavier Saintmard, Lea Vilanova Mañá, Majeed Jamakhani, Michal Reichert, Luc Willems   +8 more
doaj   +2 more sources

Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]

, 2008
Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez, Mansoor, Moizza, Moizza Mansoor, Melendez, Alirio J.   +3 more
core   +8 more sources

Making Sense out of Antisense Transcription in Human T-Cell Lymphotropic Viruses (HTLVs)

Viruses, 2011
Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' long terminal repeat (LTR), which is either unspliced or alternatively spliced.
Benoit Barbeau, Jean-Michel Mesnard
doaj   +3 more sources