Results 21 to 30 of about 861,233 (259)

Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription

Cell Reports, 2021
Lidia Vasiljeva, Soren Nielsen, Nikolay Zenkin   +2 more
exaly   +2 more sources

Widespread Antisense Transcription in Prokaryotes. [PDF]

Microbiol Spectr, 2018
ABSTRACT Although bacterial genomes are usually densely protein-coding, genome-wide mapping approaches of transcriptional start sites revealed that a significant fraction of the identified promoters drive the transcription of noncoding RNAs.
Georg J, Hess WR.
europepmc   +4 more sources

Antisense transcription from stress-responsive transcription factors fine-tunes the cold response in Arabidopsis. [PDF]

Plant Cell
Transcription of antisense long noncoding RNAs (lncRNAs) occurs pervasively across eukaryotic genomes. Only a few antisense lncRNAs have been characterized and shown to control biological processes, albeit with idiosyncratic regulatory mechanisms.
Meena SK, Quevedo M, Nardeli SM, Verez C, Bhat SS, Zacharaki V, Kindgren P.   +6 more
europepmc   +4 more sources

Natural antisense transcripts [PDF]

Human Molecular Genetics, 2014
Recent years have seen the increasing understanding of the crucial role of RNA in the functioning of the eukaryotic genome. These discoveries, fueled by the achievements of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regulatory roles of natural antisense transcripts (NATs) arising from what was previously
Olga, Khorkova, Amanda J, Myers, Jane, Hsiao, Claes, Wahlestedt   +3 more
openaire   +2 more sources

Abundant binary promoter switches in lineage-determining transcription factors indicate a digital component of cell fate determination

Cell Reports, 2023
Summary: Previous studies of the murine Ly49 and human KIR gene clusters implicated competing sense and antisense promoters in the control of variegated gene expression.
Hongchuan Li, Md Ahasanur Rahman, Michael Ruesch, Caprice D. Eisele, Erik M. Anderson, Paul W. Wright, Jennie Cao, Shashikala Ratnayake, Qingrong Chen, Chunhua Yan, Daoud Meerzaman, Roshini S. Abraham, Aharon G. Freud, Stephen K. Anderson   +13 more
doaj   +1 more source

Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation [PDF]

Molecular Cell, 2017
Patrick Cramer, Carina Demel, Peter J Park   +2 more
exaly   +2 more sources

Investigating Antisense Transcription at the HTT Locus [PDF]

, 2022
Antisense transcription is an important mechanism of gene expression regulation. Antisense RNAs play a role in mRNA processing, translation and epigenetic modifications of DNA and histones in the locus of their origin, leading to gene silencing. HTT is a
Elisaphenko, Eugeny A., Malakhova, Anastasia A.   +1 more
core   +1 more source

Antisense non-coding transcription represses the PHO5 model gene at the level of promoter chromatin structure.

PLoS Genetics, 2022
Pervasive transcription of eukaryotic genomes generates non-coding transcripts with regulatory potential. We examined the effects of non-coding antisense transcription on the regulation of expression of the yeast PHO5 gene, a paradigmatic case for gene ...
Ana Novačić, Dario Menéndez, Jurica Ljubas, Slobodan Barbarić, Françoise Stutz, Julien Soudet, Igor Stuparević   +6 more
doaj   +1 more source

Localizing hotspots of antisense transcription [PDF]

Nucleic Acids Research, 2007
Analysis of the transcriptome by computational and experimental methods has established that sense-antisense transcriptional units are a common phenomenon. Although the regulatory potential of antisense transcripts has been experimentally verified in a number of studies, the biological importance of sense-antisense regulation of gene expression is ...
Finocchiaro G, CARRO M, Francois S, Parise P, DiNinni V, Muller H   +5 more
openaire   +3 more sources

CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions

Scientific Reports, 2023
Pairs of sense and antisense transcriptions that are adjacent at their 5′ and 3′ regions are called divergent and convergent transcription, respectively. However, the structural properties of divergent/convergent transcription in different species or RNA
Maya Suzuki, Satoshi Sakai, Kosuke Ota, Yuki Bando, Chiharu Uchida, Hiroyuki Niida, Masatoshi Kitagawa, Tatsuya Ohhata   +7 more
doaj   +1 more source