Antisense transcription‐dependent chromatin signature modulates sense transcript dynamics [PDF]
Molecular Systems Biology, 2018 Antisense transcription is widespread in genomes. Despite large differences in gene size and architecture, we find that yeast and human genes share a unique, antisense transcription‐associated chromatin signature.
Thomas Brown +8 more
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Mechanisms of Antisense Transcription Initiation with Implications in Gene Expression, Genomic Integrity and Disease Pathogenesis [PDF]
Non-Coding RNA, 2019 Non-coding antisense transcripts arise from the strand opposite the sense strand. Over 70% of the human genome generates non-coding antisense transcripts while less than 2% of the genome codes for proteins.
Priyanka Barman +2 more
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Repression of meiotic genes by antisense transcription and by Fkh2 transcription factor in Schizosaccharomyces pombe. [PDF]
PLoS ONE, 2012 In S. pombe, about 5% of genes are meiosis-specific and accumulate little or no mRNA during vegetative growth. Here we use Affymetrix tiling arrays to characterize transcripts in vegetative and meiotic cells.
Huei-Mei Chen +4 more
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Strand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis. [PDF]
PLoS ONE, 2012 BACKGROUND: Although genome-wide transcriptional analysis has been used for many years to study bacterial gene expression, many aspects of the bacterial transcriptome remain undefined.
Karla D Passalacqua +6 more
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Novel perspectives on antisense transcription in HIV-1, HTLV-1, and HTLV-2 [PDF]
Frontiers in Microbiology, 2022 The genome of retroviruses contains two promoter elements (called long terminal repeat or LTR) at the 5′ and 3′ end of their genome. Although the expression of retroviral genes generally depends on the promoter located in the 5′ LTR, the 3′ LTR also has ...
Edward Lin +3 more
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High levels of antisense transcription from numerous genes in the obligate intracellular bacterium Orientia tsutsugamushi [PDF]
Journal of BacteriologyOrientia tsutsugamushi (Ot) is a cytoplasmic, gram-negative, obligate intracellular bacterium that causes the human disease scrub typhus. It has a highly repetitive genome, whereby approximately 50% is composed of multiple copies of a proliferated ...
Chitrasak Kullapanich +3 more
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Epigenetic Regulation of HIV-1 Sense and Antisense Transcription in Response to Latency-Reversing Agents [PDF]
Non-Coding RNA, 2023 Nucleosomes positioned on the HIV-1 5′ long terminal repeat (LTR) regulate sense transcription as well as the establishment and maintenance of latency.
Rui Li +4 more
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Antisense transcription can induce expression memory via stable promoter repression [PDF]
Genome BiologyBackground The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mutual repression of two genes, forming a toggle switch.
Verena Mutzel +9 more
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Evidence for antisense transcription associated with microRNA target mRNAs in Arabidopsis. [PDF]
PLoS Genetics, 2009 Antisense transcription is a pervasive phenomenon, but its source and functional significance is largely unknown. We took an expression-based approach to explore microRNA (miRNA)-related antisense transcription by computational analyses of published ...
Qing-Jun Luo +7 more
doaj +3 more sources
Cis-Antisense Transcription Gives Rise to Tunable Genetic Switch Behavior: A Mathematical Modeling Approach. [PDF]
PLoS ONE, 2015 Antisense transcription has been extensively recognized as a regulatory mechanism for gene expression across all kingdoms of life. Despite the broad importance and extensive experimental determination of cis-antisense transcription, relatively little is ...
Antoni E Bordoy, Anushree Chatterjee
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