Results 41 to 50 of about 203 (142)

Protein C and antithrombin III deficiency in an elderly patient presenting with pulmonary embolism

Asian Journal of Internal Medicine
Pulmonary embolism is a life-threatening condition, which if not detected and treated timely may lead to death. It is usually a consequence of deep vein thrombosis, which itself may occur due to several risk factors like prolonged immobilisation ...
R. Khan, N. Mahiyuddin, R. Tasnim, M. M. Rishad, Q. T. Islam   +4 more
doaj   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Thrombophilias, or trouble never comes alone

Cardiologia Hungarica
Venous thromboembolism is being recognized increasingly at a young age, with not only the etiological role of the COVID-19-pandemic being considered but also the rarer occurrences of thrombophilias and the regional clustering of certain diseases.
Márk Söjtöry, Nóra Klenk, Nóra Sebő, Gergely György Nagy   +3 more
doaj   +1 more source

Patient Preferences for the Treatment of Haemophilia A and B in France

Haemophilia, EarlyView.
ABSTRACT Introduction Haemophilia impacts health and quality of life. Advances in treatments such as factor replacement therapy (FRT), bispecific monoclonal antibody (BS‐mAb), gene therapy (GT), rebalancing treatment and high sustained factor necessitate understanding patient preferences to inform therapeutic strategies. Aim This study quantified trade‐
Yesim Dargaud, Yasmine Fahfouhi, Monia Ezzalfani, Astrid Foix Colonier, Alaeddine Sidhom, Aline Gauthier, Jérémie Rudant, Meriem Kessouri, Nicolas Giraud, Benoît Guillet, Anaïs Reynaud   +10 more
wiley   +1 more source

Hybrid treatment of recurrent venous mesenteric thrombosis with small intestinal necrosis

Acta Biomedica Scientifica
The article presents a clinical case of a 39-year-old patient with thrombosis and postoperative rethrombosis of the superior mesenteric vein. The disease was complicated by the small intestine necrosis and abdominal surgical infection.
S. E. Grigoryev, A. V. Novozhilov, E. G. Grigoryev   +2 more
doaj   +1 more source

The XX Factor in Hemophilia: Diagnostic, Therapeutic, and Research Gaps for Women and Girls

Haemophilia, EarlyView.
ABSTRACT Introduction Hemophilia has traditionally been viewed as an X‐linked disorder affecting men and boys, with women and girls labeled as “carriers”, presumed to be clinically unaffected. This paradigm has contributed to under‐recognition, delayed diagnosis, and undertreatment of females with hemophilia‐associated genotypes despite an increasingly
Kelsey Uminski, Ellen Cusano
wiley   +1 more source

Purpura fulminans associated with hemiparesis following measles infection in a Nigerian girl: A case report

Journal of Family Medicine and Primary Care, 2013
Purpura fulminans is a life-threatening hematologic emergency characterized by extensive skin necrosis with hemorrhagic infarction, hypotension and gangrene which may arise from severe sepsis; mostly gram negative sepsis though also associated with some ...
Aliyu Ibrahim
doaj   +1 more source

From Bleeding Control to Health: Implementing Multidimensional and Multidisciplinary Hemophilia Care Into the Era of Therapeutic Innovation

Haemophilia, EarlyView.
ABSTRACT Introduction Over the past decade, hemophilia management has been transformed by modern prophylactic strategies, achieving dramatic reductions in annualized bleeding rates (ABR), often approaching zero. However, the conceptual evolution of hemophilia care toward multidimensional health assessment and comprehensive multidisciplinary management ...
Nicolas Giraud, Yesim Dargaud
wiley   +1 more source

Heparin resistance management during cardiac surgery: a literature review and future directions

The Journal of ExtraCorporeal Technology
Introduction: Heparin, a commonly used anticoagulant in cardiac surgery, binds to antithrombin III (ATIII) to prevent clot formation. However, heparin resistance (HR) can complicate surgical procedures, leading to increased thromboembolic risks and ...
Butt Salman Pervaiz, Kakar Vivek, Kumar Arun, Razzaq Nabeel, Saleem Yasir, Ali Babar, Raposo Nuno, Ashiq Fazil, Ghori Arshad, Anderson Philip, Srivatav Nilesh, Aljabery Yazan, Abdulaziz Salman, Darr Umer, Bhatnagar Gopal   +14 more
doaj   +1 more source

AORTIC AND SUPERIOR MESENTERIC ARTERY THROMBOSIS IN ANTITHROMBIN III DEFICIENCY-DIAGNOSTIC AND THERAPEUTIC CHALLENGES IN CONSERVATIVE MANAGEMENT [PDF]

Sanamed
Introduction: Thrombosis of large arterial vessels, such as the abdominal aorta and superior mesenteric artery, is a rare but serious condition that requires timely diagnosis and appropriate management. One of the risk factors is antithrombin III (AT III)
Surla Dimitrije, Nikolic Marija, Trifunovic Nemanja, Stojadinovic Milica   +3 more
doaj   +1 more source