Results 41 to 50 of about 14,443 (215)

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile [PDF]

, 2016
Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors.
Afosa, Daniel K., Al-Horani, Rami A., Desai, Umesh R., Karuturi, Rajesh, Lee, Michael   +4 more
core   +9 more sources

Estetrol‐based combined oral contraceptives: A systematic review of clinical outcomes

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This systematic review summarizes clinical outcomes of estetrol‐containing combined oral contraceptives, showing reliable contraceptive efficacy, predictable bleeding patterns, improved well‐being, and a favorable hemostatic and metabolic profile, suggesting a promising and potentially safer alternative to ethinylestradiol‐based formulations.
Mathilde Råberg, Ingeborg Rose Vad, Kara Hildur Axelsdóttir, Ellen Christine Leth Løkkegaard   +3 more
wiley   +1 more source

Identification of Coagulation Phenotypes Using Viscoelastic and Conventional Assays During Veno‐Venous Extracorporeal Membrane Oxygenation: A Hierarchical Clustering Analysis

Artificial Organs, EarlyView.
Hierarchical clustering of viscoelastic and conventional coagulation parameters identified three distinct phenotypes in V‐V ECMO patients, revealing substantial APTT–CK‐R discordance and highlighting the value of TEG‐derived markers for detecting coagulopathy not captured by standard monitoring.
Daisuke Irimada, Yudai Iwasaki, Yusuke Takei, Moe Oyama, Ami Tanaka, Shinichi Yamaguchi, Naoya Kobayashi, Daisuke Konno, Takuya Shiga, Masanori Yamauchi   +9 more
wiley   +1 more source

Comparison of antithrombin activity assays in detection of patients with heparin binding site antithrombin deficiency: systematic review and meta-analysis

Scientific Reports, 2023
Antithrombin (AT) deficiency increases the risk for venous thromboembolism, therefore, a highly sensitive assay to identify this condition is crucial. The aim of this paper was to perform a meta-analysis comparing AT activities measured by different AT ...
Tamara Rojnik, Nataša Sedlar, Nana Turk, Andrej Kastrin, Maruša Debeljak, Mojca Božič Mijovski   +5 more
doaj   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss

Libyan Journal of Medicine
To evaluate the predictive role of serum amyloid A (SAA) levels and their association with antiphospholipid antibodies (APA) and coagulation markers such as lupus anticoagulants (LA), anti-cardiolipin (ACA), protein C (PC) deficiency, protein S (PS ...
Mahmoud Thabet, Kawkab Ali Hasan, Ismail A. Elhefnawy, Ghada Barakat, Dalia Moemen, Ahmed Ragab, Dalia Mahmoud Abdelmonem Elsherbini, Mohamed El-Sherbiny, Nagwan Ahmed Bahgat, Maged Ragheb Elshamy, Rayan G. Albarakati, Baisakhi Kar, Sara Izzeldin Hassan, Spogmai Arif, Saima Reshi, Abida Ikram, Rebecamma Ommen, Nayla Jamal Bushaqer, Mahmoud Mohamed Abdel-Razik, Waleed Eldars   +19 more
doaj   +1 more source

Molar‐Incisor Hypomineralisation in Children: The Essential Role of Paediatricians

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim Molar‐incisor hypomineralisation is a developmental enamel defect characterised by lower mineral content in the tooth's outer layer, discoloured and structurally fragile teeth that are more prone to sensitivity, breakdown and caries. This review aims to summarise current knowledge on molar‐incisor hypomineralisation and highlight key ...
Sofia Stancati, Viviana Macho, Rita Rodrigues, Cristina Cardoso Silva   +3 more
wiley   +1 more source

Use of recombinant human antithrombin concentrate in pregnancy

International Journal of Women's Health, 2013
Lisa M Baumann Kreuziger,1 Tracy L Prosen,2 Mark T Reding1 1Division of Hematology, Oncology, and Transplantation, University of Minnesota, MN, USA; 2Obstetrics and Gynecology, Maternal Fetal Medicine Center, University of Minnesota, MN, USAWe read with ...
Baumann Kreuziger LM, Prosen TL, Reding MT   +2 more
doaj  

Clinical management and outcomes for 51 Pugs reportedly diagnosed with protein‐losing enteropathy using VetCompass primary care veterinary data

Journal of Small Animal Practice, EarlyView.
Objectives To report the clinicopathological findings, treatment and outcomes of Pugs diagnosed with protein‐losing enteropathy using VetCompass primary care clinical data in the UK and to determine if referral or any specific treatments for protein‐losing enteropathy were associated with outcome. Materials and Methods Retrospective VetCompass study of
A. Kathrani, D. C. Brodbelt, D. B. Church, D. G. O’Neill   +3 more
wiley   +1 more source

Bilateral renal artery thrombosis in inherited thrombophilia: a rare cause of acute kidney injury

International Journal of Nephrology and Renovascular Disease, 2014
Kate S Wiles,1 Laura Hastings,1 Vasantha Muthu Muthuppalaniappan,1 Muhammad Hanif,2 Sumith Abeygunasekara11Department of Medicine, 2Department of Radiology, Mid Essex Hospital Services NHS Trust, Chelmsford, UKAbstract: We describe the case of a 47-year ...
Wiles KS, Hastings L, Muthuppalaniappan VM, Hanif M, Abeygunasekara S   +4 more
doaj