Results 41 to 50 of about 7,596 (176)

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Use of recombinant human antithrombin concentrate in pregnancy

International Journal of Women's Health, 2013
Lisa M Baumann Kreuziger,1 Tracy L Prosen,2 Mark T Reding1 1Division of Hematology, Oncology, and Transplantation, University of Minnesota, MN, USA; 2Obstetrics and Gynecology, Maternal Fetal Medicine Center, University of Minnesota, MN, USAWe read with ...
Baumann Kreuziger LM, Prosen TL, Reding MT   +2 more
doaj  

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Bilateral renal artery thrombosis in inherited thrombophilia: a rare cause of acute kidney injury

International Journal of Nephrology and Renovascular Disease, 2014
Kate S Wiles,1 Laura Hastings,1 Vasantha Muthu Muthuppalaniappan,1 Muhammad Hanif,2 Sumith Abeygunasekara11Department of Medicine, 2Department of Radiology, Mid Essex Hospital Services NHS Trust, Chelmsford, UKAbstract: We describe the case of a 47-year ...
Wiles KS, Hastings L, Muthuppalaniappan VM, Hanif M, Abeygunasekara S   +4 more
doaj  

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

WARFARIN INDUCED MASSIVE AND BILATERAL SKIN NECROSIS OF THE BREASTS: A CASE REPORT AND REVIEW OF THE LITERATURES [PDF]

Acta Medica Iranica, 2005
Warfarin induced skin necrosis is a rare complication associated with the use of oral ‎anticoagulants. Most patients develop this complication at the initiation of therapy. The complication is ‎usually associated with an underlying thrombophilia. Here we
A. R. Taheri H. Abdali
doaj   +2 more sources

Protein C and antithrombin III deficiency in an elderly patient presenting with pulmonary embolism

Asian Journal of Internal Medicine
Pulmonary embolism is a life-threatening condition, which if not detected and treated timely may lead to death. It is usually a consequence of deep vein thrombosis, which itself may occur due to several risk factors like prolonged immobilisation ...
R. Khan, N. Mahiyuddin, R. Tasnim, M. M. Rishad, Q. T. Islam   +4 more
doaj   +1 more source

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

Thrombophilias, or trouble never comes alone

Cardiologia Hungarica
Venous thromboembolism is being recognized increasingly at a young age, with not only the etiological role of the COVID-19-pandemic being considered but also the rarer occurrences of thrombophilias and the regional clustering of certain diseases.
Márk Söjtöry, Nóra Klenk, Nóra Sebő, Gergely György Nagy   +3 more
doaj   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 745-768, July/August 2026.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source