Results 31 to 40 of about 7,596 (176)

Genetic and clinical characterization of two families with severe venous thromboembolism due to nonsense mutations in the SERPINC1 gene. [PDF]

Thromb J
Antithrombin (AT) III is a key physiological anticoagulant, and its hereditary deficiency represents one of the most severe forms of inherited thrombophilia.
Wei X, Chen W, Zhang J, Mao J.
europepmc   +2 more sources

Comparison of Protective Effects of Recombinant Antithrombin Gamma and Plasma-Derived Antithrombin on Sepsis-Induced Disseminated Intravascular Coagulation and Multiple Organ Failure

Clinical and Applied Thrombosis/Hemostasis, 2020
In Japan, the dose of the new recombinant antithrombin III concentrate (rAT-gamma) is titrated according to patient body weight (BW), while conventional plasma-derived antithrombin concentrates (AT) are administered as a fixed dose.
Hiromitsu Kuroda MD, Yoshiki Masuda MD, PhD   +1 more
doaj   +1 more source

Hemostatic system changes predictive value in patients with ischemic brain disorders [PDF]

Vojnosanitetski Pregled, 2002
The aim of this research was to determine the importance of tracking the dynamics of changes of the hemostatic system factors (aggregation of thrombocytes, D-dimer, PAI-1, antithrombin III, protein C and protein S, factor VII and factor VIII, fibrin ...
Raičević Ranko, Jovičić Aco, Mandić-Radić Slavka, Đorđević Dragana, Magdić Bratislav, Marković Ljubo, Veljančić Dragana, Dinčić Evica, Obradović Slobodan   +8 more
doaj   +1 more source

Deficiency of Natural Anticoagulants Involves in the Occurrence of Arterial Thrombosis

Plasmatology, 2023
Background The role of natural anticoagulant deficiency in the development of arterial thrombosis (AT) is controversial. Objective Our objectives were to assess the deficiency of natural anticoagulants, including protein S (PS), protein C (PC ...
Thi Tuyet Mai Nguyen MD, Minh Phuong Vu MD, PhD, Tuan Tung Nguyen MD, PhD, Hai Yen Duong MD   +3 more
doaj   +1 more source

Infartos cerebrais em pacientes jovens relacionados a deficiência de anticoagulantes naturais proteína C e proteína S Protein C and S deficiencies related stroke in young patients

Arquivos de Neuro-Psiquiatria, 1996
Infartos cerebrais (IC) em jovens apresentam múltiplas etiologias que diferem do padrão observado nos indivíduos idosos. Deficiências de anticoagulantes naturais têm sido descritas nos últimos anos como causa de IC, principalmente em pacientes com menos ...
José Ibiapina Siqueira Neto, Antonio C. Santos, Soraia R. Cabette Fábio, Américo C. Sakamoto   +3 more
doaj   +1 more source

Priming of labor with tafoxiparin in nulliparous term pregnant women with unripe cervix—Proof‐of‐concept and dose‐finding results from a randomized controlled trial

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This study shows that tafoxiparin 300 mg can increase the rate of cervical ripening and the likelihood of spontaneous onset of labor, while also reducing the duration of labor in women achieving spontaneous onset of labor. The favorable safety profile of tafoxiparin suggests suitability for routine clinical use, including home administration.
Gunvor Ekman‐Ordeberg, Maria Jonsson, Marie Blomberg, Malin Melin, Ylva Stjernholm‐Vladic, Sebastian B. Gidlöf, Dag Wide‐Swensson, Kati Tihtonen, Inge C. Olsen, Lena Degling‐Wikingsson, Per Blom, Leena Rahkonen   +11 more
wiley   +1 more source

Identification of Coagulation Phenotypes Using Viscoelastic and Conventional Assays During Veno‐Venous Extracorporeal Membrane Oxygenation: A Hierarchical Clustering Analysis

Artificial Organs, EarlyView.
Hierarchical clustering of viscoelastic and conventional coagulation parameters identified three distinct phenotypes in V‐V ECMO patients, revealing substantial APTT–CK‐R discordance and highlighting the value of TEG‐derived markers for detecting coagulopathy not captured by standard monitoring.
Daisuke Irimada, Yudai Iwasaki, Yusuke Takei, Moe Oyama, Ami Tanaka, Shinichi Yamaguchi, Naoya Kobayashi, Daisuke Konno, Takuya Shiga, Masanori Yamauchi   +9 more
wiley   +1 more source

Comparison of antithrombin activity assays in detection of patients with heparin binding site antithrombin deficiency: systematic review and meta-analysis

Scientific Reports, 2023
Antithrombin (AT) deficiency increases the risk for venous thromboembolism, therefore, a highly sensitive assay to identify this condition is crucial. The aim of this paper was to perform a meta-analysis comparing AT activities measured by different AT ...
Tamara Rojnik, Nataša Sedlar, Nana Turk, Andrej Kastrin, Maruša Debeljak, Mojca Božič Mijovski   +5 more
doaj   +1 more source

Anticoagulation Strategies in Adults Undergoing Extracorporeal Membrane Oxygenation: A Systematic Review and Meta‐Analysis

Artificial Organs, EarlyView.
In this meta‐analysis of 2 775 adult ECMO patients from non‐randomized studies, direct thrombin inhibitors and low‐molecular‐weight heparins demonstrated a favorable efficacy and safety profile over unfractionated heparin. These findings suggest them to be effective alternatives to unfractionated heparin, underscoring the urgent need for randomized ...
Vincenz Scharner, Karoline Lenz, Harald Herkner, Nina Buchtele, Thomas Staudinger, Eva Schaden, Marion Wiegele, Johannes Gratz   +7 more
wiley   +1 more source

Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss

Libyan Journal of Medicine
To evaluate the predictive role of serum amyloid A (SAA) levels and their association with antiphospholipid antibodies (APA) and coagulation markers such as lupus anticoagulants (LA), anti-cardiolipin (ACA), protein C (PC) deficiency, protein S (PS ...
Mahmoud Thabet, Kawkab Ali Hasan, Ismail A. Elhefnawy, Ghada Barakat, Dalia Moemen, Ahmed Ragab, Dalia Mahmoud Abdelmonem Elsherbini, Mohamed El-Sherbiny, Nagwan Ahmed Bahgat, Maged Ragheb Elshamy, Rayan G. Albarakati, Baisakhi Kar, Sara Izzeldin Hassan, Spogmai Arif, Saima Reshi, Abida Ikram, Rebecamma Ommen, Nayla Jamal Bushaqer, Mahmoud Mohamed Abdel-Razik, Waleed Eldars   +19 more
doaj   +1 more source