Results 31 to 40 of about 37,585 (155)

Relapse of aplastic anemia in children after immunosuppressive therapy: a report from the Japan Childhood Aplastic Anemia Study Group

Haematologica, 2011
Background Although the therapeutic outcome of acquired aplastic anemia has improved markedly with the introduction of immunosuppressive therapy using antithymocyte globulin and cyclosporine, a significant proportion of patients subsequently relapse and ...
Takuya Kamio, Etsuro Ito, Akira Ohara, Yoshiyuki Kosaka, Masahiro Tsuchida, Hiroshi Yagasaki, Hideo Mugishima, Hiromasa Yabe, Akira Morimoto, Shouichi Ohga, Hideki Muramatsu, Asahito Hama, Takashi Kaneko, Masayuki Nagasawa, Atsushi Kikuta, Yuko Osugi, Fumio Bessho, Tatsutoshi Nakahata, Ichiro Tsukimoto, Seiji Kojima   +19 more
doaj   +1 more source

Identification of sex hormone-binding globulin in the human hypothalamus [PDF]

, 2005
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Caldwell, Jack D., Eggeling, Ferdinand von, Bernstein, Hans-Gert, Melle, Christian, Jirikowski, Gustav F., Lewis, John, Herbert, Zsófia, Göthe, Susanne   +7 more
core   +1 more source

Current evidence and insights on single vs. double dose of basiliximab in adult solid organ transplant recipients: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this systematic review was to assess all available clinical data regarding the use of a single dose of basiliximab in solid organ transplantation compared to the standard double dosage, with particular interest in efficacy, safety and cost‐savings.
Alessio Provenzani, Braidon A. Lape, Anneliese M. Harp, Victoria Weisbrod, Lavinia Piazza   +4 more
wiley   +1 more source

Dynamic early biomarkers predict outcomes in pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis

Pediatric Investigation, EarlyView.
This study elucidates the critical pathogenic mechanisms of pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis (EBV‐HLH), where EBV infection triggers a cytokine storm leading to immune cell hyperactivation and tissue damage. Dynamic plasma biomarkers (EBV‐DNA, ferritin, and interferon‐γ) effectively predict treatment response ...
Feifei Liu, Qing Zhang, Sitong Chen, Yunze Zhao, Dong Wang, Hongyun Lian, Honghao Ma, Tianyou Wang, Rui Zhang, Zhigang Li   +9 more
wiley   +1 more source

Myelodysplastic syndromes: Aspects of current medical care and economic considerations in Germany [PDF]

, 2008
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases mainly affecting older people. The use of an increasing number of therapeutic options depends on a systematic risk stratification of the patients.
Gattermann, Norbert, Karin Berger, Hofmann, Wolf-Karsten, Tsamaloukas, Anton, Wolf-Karsten Hofmann, Vollmer, Tanja, Plesnila-Frank, Carlotta, Berger, Karin, Wedding, Ulrich, Schramm, Wolfgang, Tanja Vollmer, Schmitz, Stephan, Wolfgang Schramm, Norbert Gattermann, Ulrich Wedding, Meeßen, Axel, Carlotta Plesnila-Frank, Stephan Schmitz, Axel Meessen, Anton Tsamaloukas   +19 more
core   +1 more source

CD3 monitoring of antithymocyte globulin therapy in thoracic organ transplantation.

, 2002
BACKGROUND: Antithymocyte globulin is frequently used as a component of induction therapy in thoracic organ transplantation. This study evaluates the utility of monitoring peripheral CD3 lymphocytes to rationally adjust antithymocyte globulin therapy in ...
Kamoun, Malek, Acker, Michael A, Bavaria, Joseph E, MD, Arcasoy, Selim, Krasinskas, Alyssa M, Blumenthal, Nancy, Rosengard, Bruce R, Pochettino, Alberto, Kreisel, Daniel, Moore, Jonni S, Kotloff, Robert M   +10 more
core   +1 more source

Long-term follow up after allogeneic stem cell transplantation in patients with severe aplastic anemia after cyclophosphamide plus antithymocyte globulin conditioning

Haematologica, 2012
Background Due to increased rates of secondary solid organ cancer in patients with severe aplastic anemia who received an irradiation-based conditioning regimen, we decided some years ago to use the combination of cyclophosphamide and antithymocyte ...
Johanna Konopacki, Raphaël Porcher, Marie Robin, Sabine Bieri, Jean-Michel Cayuela, Jérôme Larghero, Aliénor Xhaard, Anna Lisa Andreoli, Nathalie Dhedin, Anna Petropoulou, Paula Rodriguez-Otero, Patricia Ribaud, Hélène Moins-Teisserenc, Maryvonnick Carmagnat, Antoine Toubert, Yves Chalandon, Gérard Socie, Régis Peffault de Latour   +17 more
doaj   +1 more source

An Experience of Donor Lymphocyte Infusion after Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease

Pediatric Reports, 2020
Allogeneic hematopoietic stem-cell transplantation is a well-known curative treatment for patients with chronic granulomatous disease. We present our experiment regarding ten patients with chronic granulomatous disease who underwent a reduced intensity ...
Tahereh Rostami, Azadeh Kiumarsi
doaj   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Antithymocyte globulin/antilymphocyte globulin plus kidney-nourishing Chinese Medicinal: effect on severe aplastic anemia [PDF]

, 2012
ObjectiveTo explore the effect of antithymocyte globulin (ATG)/antilymphocyte globulin (ALG) plus kidney-nourishing Chinese medicinal (KNCM) on severe aplastic anemia (SAA).MethodsTwenty-five subjects of severe aplastic anemia were treated with ATG/ALD ...
Ma, Rou, Liu, Chi, Tang, Xudong, Li, Liu, Xiao, Haiyan, Zhang, Shanshan, Xu, Shu, Liu, Feng, Zheng, Chunmei   +8 more
core   +1 more source