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The potential for repositioning antithyroid agents as antiasthma drugs

The potential for repositioning antithyroid agents as antiasthma drugs
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Recurrent agranulocytosis induced by two different antithyroid agents

Medical Journal of Australia, 1983
A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil. When the thyrotoxicosis recurred, accompanied by a severe psychotic reaction, administration of antithyroid medication was recommenced. The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.
B, Chen, R, Lang, Y, Jutrin, M, Ravid
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ANTITHYROID AGENTS

Archives of Dermatology and Syphilology, 1948
Recently certain synthetic materials have been found that oppose the formation of thyroxin, the active principle of the thyroid gland. This newer group consists of a number of substances, of which thiouracil and propylthiouracil have become the best known.
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AN INTERPRETATION OF THE GOITROGENIC PROPERTIES OF CERTAIN “ANTITHYROID” AGENTS*†

The Journal of Clinical Endocrinology & Metabolism, 1950
THE discovery of the antithyroid activity of certain drugs furnished a tool and a renewed stimulus for the study of the mechanism of thyroid function. One of these agents, thiouracil, was early recognized as an effective chemotherapeutic agent for the control of thyrotoxicosis.
F X, GASSNER, M L, HOPWOOD, E A, HERROLD, A J, PLUMMER   +3 more
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The Biology of Antithyroid Agents

1947
Publisher Summary This chapter explains that recent work on the antithyroid agents has provided a new approach to the study of thyroid physiology. It has not only made available effective chemical weapons for combating toxic goiter but has also made material contribution to a further understanding of the basic reactions underlying the functioning of ...
Harry A. Charipper, Albert S. Gordon
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[Fever due to antithyroid agents].

Nederlands tijdschrift voor geneeskunde, 1999
Three patients, females aged 62, 67 and 32 years, were presented with fever and sore throat and had severe agranulocytosis (granulocyte count < 100/microliter). All had Graves' disease and were being treated with thiamazole 30 mg once a day. Thiamazole was discontinued and treatment with antibiotics initiated.
S O, Shamelian, J W, Nortier
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Beta blocking agents and antithyroid drugs as adjuncts to radioiodine therapy

Seminars in Nuclear Medicine, 1971
Since the major beneficial effects of 131 I therapy are often delayed for 3 to 5 mo or even longer, it is essential to provide more rapid control of thyrotoxic manifestations, particularly in severely ill patients or in those with complications, such as heart failure or psychosis.
K, Sterling, R, Hoffenberg
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[Antithyroid agents and embryopathies].

Annales d'endocrinologie, 2004
First cause of hyperthyroidism among women of childbearing age, Graves' disease raises the risk of maternal and fetal complications, including eclampsia, cardiac failure, abortion, prematurity, fetal death, all of which can be avoided if maternal hyperthyroidism is closely controlled.
Cl, Bournaud, J, Orgiazzi
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Examination of antithyroid effects of smoking products in cultured thyroid follicles: only thiocyanate is a potent antithyroid agent

Acta Endocrinologica, 1992
We studied the antithyroid action of cigarette smoking products (nicotine, cotinine, and thiocyanate) in the physiological culture system of porcine thyroid follicles. Iodide uptake, iodine organification, de novo thyroid hormone formation, and iodide efflux were measured in the presence of 0–200 μmol/l nicotine, cotinine, or potassium thiocyanate ...
H, Fukayama, M, Nasu, S, Murakami, M, Sugawara   +3 more
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