From antithyroid therapy to oral necrosis: oral manifestations of methimazole-induced agranulocytosis: a case report [PDF]
Journal of Medical Case ReportsBackground Methimazole is a widely used antithyroid medication with a well-documented risk of hematological adverse effects, particularly agranulocytosis.
Haitham Medhioub +5 more
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Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine [PDF]
Advanced Pharmaceutical Bulletin, 2014 Purpose: Methimazole is the most convenient drug used in the management of hyperthyroid patients. However, associated with its clinical use is hepatotoxicity as a life threatening adverse effect.
Reza Heidari +3 more
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Cytoprotective Effects of Organosulfur Compounds against Methimazole-Induced Toxicity in Isolated Rat Hepatocytes [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Methimazole is a drug widely used in hyperthyroidism. However, life-threatening hepatotoxicity has been associated with its clinical use. No protective agent has been found to be effective against methimazole-induced hepatotoxicity yet.
Mohammad Ali Eghba +2 more
doaj +1 more source
The Role of Endoplasmic Reticulum Stress in Cell Injury Induced by Methimazole on Pancreatic Cells [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: Methimazole is an anti-thyroid agent, especially as main therapy option for Graves’ disease in children and adults. Drug induced pancreatitis is one of the known adverse effect of methimazole mentioned in case reports.
Özge Yazıcı +3 more
doaj +1 more source
Metabolite Changes during the Transition from Hyperthyroidism to Euthyroidism in Patients with Graves’ Disease [PDF]
Endocrinology and Metabolism, 2022 Background An excess of thyroid hormones in Graves’ disease (GD) has profound effects on systemic energy metabolism that are currently partially understood.
Ho Yeop Lee +9 more
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Colorimetric Determination of Thioamide Drugs Based on the Surface Plasmon Resonance Band of Colloidal Silver Nanoparticles [PDF]
شیمی کاربردی روز, 2013 In this article, we report a new method for the determination of two thioamide drugs, propylthiouracil (PTU) and methimazole (MMZ), with unmodified silver nanoparticles (AgNPs).
Jafar Abolhasani +3 more
doaj +1 more source
Frontiers in Endocrinology, 2021 BackgroundHyperthyroidism is related to vascular atherosclerosis. Propylthiouracil (PTU) and methimazole, other than their antithyroid effects, may have different mechanisms in preventing atherogenesis in Graves’ disease.ObjectiveThis study aimed to ...
Wismandari Wisnu +9 more
doaj +1 more source
Preparation of Au@Ir/C as sensor for Methimazole Detection
International Journal of Electrochemical Science, 2018 Au@Ir/C nanocomposite as an electroactive material for methimazole detection has been synthesized via polyol reduction method. Physical tests demonstrate that ultrafine nanoparticles of Au@Ir composite (2-4 nm) are evenly dispersed on carbon.
Si Chen +8 more
doaj +1 more source
Effects of Thymoquinone on Hypothalamic NPY and AgRP Gene Expression in Intact and Hypothyroidism- Model Rats [PDF]
Journal of Advanced Biomedical Sciences, 2022 Background & Objective: Thymoquinone is the most important compound of Nigella sativa, which stimulates the activity of thyroid axis in healthy individuals and people with hypothyroidism.
Nasrin Ghahremani, Fariba Mahmoudi
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